A de novo approach to the formal total synthesis of the macrolide natural product (-)-virginiamycin M2 has been achieved via a convergent approach. The absolute and relative stereochemistry of the nonpeptide portion of (-)-virginiamycin M2 was introduced by two Sharpless asymmetric dihydroxylation reactions.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2527507 | PMC |
| http://dx.doi.org/10.1021/ol071145e | DOI Listing |
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