The widespread use of instrumentation in the lumbar spine has led to high rates of fusion. This has been accompanied by a marked rise in adjacent-segment disease, which is considered to be an increasingly common and significant consequence of lumbar or lumbosacral fusion. Numerous biomechanical studies have demonstrated that segments fused with rigid metallic fixation lead to significant amounts of supraphysiological stress on adjacent discs and facets. The resultant disc degeneration and/or stenosis may require further surgical intervention and extension of the fusion to address symptomatic adjacent-segment disease. Recently, dynamic stabilization implants and disc arthroplasty have been introduced as an alternative to rigid fixation. The scope of spinal disease that can be treated with this novel technology, however, remains limited, and these treatments may not apply to patients who still require rigid stabilization and arthrodesis. In the spectrum between rigid metallic fixation and motion-preserving arthroplasty is a semirigid type of stabilization in which a construct is used that more closely mirrors the modulus of elasticity of natural bone. After either interbody or posterolateral arthrodesis is achieved, the fused segments will not generate the same adjacent-level forces believed to be the cause of adjacent-segment disease. Although this form of arthrodesis does not completely prevent adjacent-segment disease, the dynamic component of this stabilization technique may minimize its occurrence. The authors report their initial experience with the use of posterior dynamic stabilization in which polyetheretherketone rods were used for a posterior construct. The biomechanics of dynamic stabilization are discussed, clinical indications are reviewed, and case studies for its application are presented.
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http://dx.doi.org/10.3171/foc.2007.22.1.11 | DOI Listing |
Chem Sci
January 2025
School of Chemistry and Chemical Engineering, Chongqing Key Laboratory of Chemical Theory and Mechanism, Chongqing University Chongqing 401331 China
Atomically precise gold nanoclusters have shown great promise as model electrocatalysts in pivotal electrocatalytic processes such as the hydrogen evolution reaction (HER) and carbon dioxide reduction reaction (CORR). Although the influence of ligands on the electronic properties of these nanoclusters is well acknowledged, the ligand effects on their electrocatalytic performances have been rarely explored. Herein, using [Au(SR)] nanoclusters as a prototype model, we demonstrated the importance of ligand hydrophilicity hydrophobicity in modulating the interface dynamics and electrocatalytic performance.
View Article and Find Full Text PDFBurns Trauma
January 2025
Department of Arthroscopic Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, No. 600 Yishan Road, Xuhui District, Shanghai 200233, China.
Objective: Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder that significantly impairs muscle regeneration following injuries, contributing to numerous complications and reduced quality of life. There is an urgent need for therapeutic strategies that can enhance muscle regeneration and alleviate these pathological mechanisms. In this study, we evaluate the therapeutic efficacy of W-GA nanodots, which are composed of gallic acid (GA) and tungstate (W6+), on muscle regeneration in type 2 diabetes mellitus (T2D)-induced muscle injury, with a focus on their anti-inflammatory and antioxidative effects.
View Article and Find Full Text PDFFam Relat
December 2024
College of Health and Human Sciences, San José State University, San José, CA.
Objective: Guided by Gottman's framework of marital stability and the ecological theories, the present study aims to understand the relationships between work-family spillover and marital stability within two levels of context-the relational and social cultural contexts.
Background: The relational context of marriage is manifested by spousal relationships-spousal support and strain, which would moderate the relationship between work-family spillover and marital stability. Identified relationships also unfold within sociocultural contexts.
Biochem Biophys Rep
March 2025
Department of Integrative Biology, School of Biosciences and Technology, Vellore Institute of Technology (VIT), Vellore, 632014, Tamil Nadu, India.
The rising resistance to fluoroquinolones in Typhimurium poses a significant global health challenge. This computational research addresses the pressing need for new therapeutic drugs by utilizing various computational tools to identify potential natural compounds that can inhibit the triple mutant DNA gyrase subunit A enzyme, which is crucial in fluoroquinolone resistance. Initially, the three-dimensional structure of the wild-type DNA gyrase A protein was modeled using homology modeling, and followed by mutagenesis to create the clinically relevant triple mutant (SER83PHE, ASP87GLY, ALA119SER) DNA gyrase A protein structure.
View Article and Find Full Text PDFData Brief
February 2025
UMR SAS, INRAE, Institut Agro, 35 000 Rennes, France.
Forage crop rotations including grasslands, common in dairy systems, are known to ensure good productivity and limit the decrease of soil organic matter frequently observed in permanent arable land. A dataset was built to compile data from the Kerbernez long-term experiment, conducted in Brittany(France) from 1978 to 2005. This experiment compared the effect of different forage crop rotations fertilized with ammonium nitrate and/or slurry, with or without grassland, on forage production (quantity, quality) and changes in soil physio-chemical characteristics.
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