Clinical signs of cardiac involvement can be the first presentation of systemic sarcoidosis. In young or middle-aged patients presenting with conduction abnormalities cardiac sarcoidosis should always be included in the differential diagnosis. If the diagnosis is made before severe systolic dysfunction has occurred, treatment with steroids can render excellent results.
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http://dx.doi.org/10.2143/AC.62.3.2020821 | DOI Listing |
BMJ Open Gastroenterol
January 2025
Inflammatory Bowel Disease Center and Division of Gastroenterology and Hepatology, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Objective: Etrasimod is an oral, once-daily, selective sphingosine 1-phosphate (S1P) receptor modulator for the treatment of moderately to severely active ulcerative colitis (UC). S1P receptor expression on cardiac cells is involved in cardiac conduction. We report cardiovascular treatment-emergent adverse events (TEAEs) associated with S1P receptor modulators and other cardiovascular events in the etrasimod UC clinical programme.
View Article and Find Full Text PDFCureus
December 2024
Cardiology, Wright State University Boonshoft School of Medicine, Dayton, USA.
Permanent pacemaker (PPM) implantation is the standard of care in patients with complete heart block (CHB) and second-degree type II atrioventricular (AV) block irrespective of patient symptoms when the conduction abnormality is irreversible. CHB generally constitutes a medical emergency that can be fatal if not urgently treated. This is in contrast to first-degree AV block and second-degree type I AV block, which require PPM implantation only in very special circumstances.
View Article and Find Full Text PDFLife (Basel)
December 2024
Thoracic Surgery Unit, Careggi University Hospital, 50134 Florence, Italy.
Pectus excavatum (PE) can be associated with either congenital or acquired heart disease. This study highlights the importance of PE surgical repair in cases of severe chest depression on the heart in underlying cardiac diseases exacerbating cardiopulmonary impairment. From January 2023 to March 2024, four male patients underwent PE repair, having heart disease including pericarditis, mitral valve prolapse, ventricular fibrillation arrest and type 1 second-degree atrioventricular block.
View Article and Find Full Text PDFNeurol Sci
December 2024
Division of Cardiology, Cardio-Thoracic Department, University Hospital of Verona, Verona, Italy.
Background: Implantable loop recorders (ILRs) have been shown to significantly improve the detection of atrial fibrillation (AF) in patients with embolic stroke of undetermined source (ESUS). The incidence and characterization of bradyarrhythmias in this subset of patients is still unknown.
Methods: All consecutive patients who received ILRs, after an ESUS, between March 2015 and December 2022 in our Center were retrospectively enrolled and analyzed.
Am J Case Rep
December 2024
Department of Cardiac Pacing and Electrophysiology, Fortis Escorts Heart Institute (FEHI), New Delhi, India.
BACKGROUND Second-degree atrioventricular (AV) block is a frequently encountered conduction abnormality on surface electrocardiogram (ECG). However, it does not always imply a block at the AV nodal level. In rare cases, this block can occur below the bundle of His, within the infra-Hisian region of the His-Purkinje system.
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