DNA methylation markers: a versatile diagnostic tool for routine clinical use.

Curr Opin Mol Ther

Epigenomics AG, Kleine Praisidentenstrasse 1, 10178 Berlin, Germany.

Published: June 2007

AI Article Synopsis

  • New treatment options for different types of cancers (neoplasias) have emerged recently.
  • There is a growing need for biomarkers to enhance diagnosis and choose effective treatments.
  • DNA methylation biomarkers are highlighted as promising because they connect directly to tumor biology and can be easily measured using standard patient samples.

Article Abstract

In recent years, several new options have been introduced for the treatment of various neoplasias. Biomarkers are urgently needed to improve diagnosis and treatment selection. DNA metlhylation biomarkers unite these desirable characteristics because they relate to key aspects of tumor biology and can be measured reliably on routinely available patient specimens. Recent improvements in DNA methylation marker discovery and efforts to transfer these into routine clinical use are summarized in this review.

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