AI Article Synopsis
- In Thailand, HIV-1 strains include CRF01_AE, subtype B, and some recombinants, highlighting the diversity of the virus in the region.
- A study using enhanced MHAbce methods identified new strains of HIV-1, revealing a complex recombinant pattern distinct from previously known CRF15_01B.
- Three strains confirmed to be part of a new recombinant form called CRF34_01B were found in individuals without known connections, emphasizing the need for improved HIV prevention and treatment strategies among injection drug users (IDU).
Article Abstract
In Thailand, the circulating HIV-1 strains include CRF01_AE, subtype B, and their recombinants. Genotyping and full-genome sequencing had previously identified circulating recombinant form CRF15_01B within a cohort of 347 HIV-1-infected individuals enrolled in the Opiate Users Research (OUR) study in northern Thailand. Using an improved MHAbce in six to eight genome regions and archived OUR serum samples, seven strains were identified with a new and complex 01/B recombinant pattern in common, different from that of CRF15_01B. Complete sequencing of three strains, amplified from serum as overlapping half-genomes, confirmed their common recombinant structure, mostly CRF01_AE, but with segments of subtype B in pol and gp41, plus a region of frequent 01/B crossovers in pol. OUR strains 1969P, 2275P, and 2478P were from individuals without direct epidemiological linkage and thus establish CRF34_01B. More comprehensive HIV-1 prevention and treatment programs in IDU can help to limit the growing complexity of HIV-1 strains in Thailand.
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| http://dx.doi.org/10.1089/aid.2006.0300 | DOI Listing |
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