Japodagrin (1) and japodagrone (2), two macrocylic diterpenoids possessing lathyrane and jatrophane skeletons, respectively, have been isolated from the root of Jatropha podagrica Hook. Four other diterpenoids (3-6) were also isolated from this plant. The structures of these compounds were elucidated on the basis of NMR and HRMS analysis, and by spectral comparisons. The compounds displayed antibacterial activity against some gram-positive bacteria.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.phytochem.2007.05.021 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Cancer therapeutic potential of hovetrichoside C from Jatropha podagrica on apoptosis of MDA-MB-231 human breast cancer cells.
Food Chem Toxicol
August 2024
School of Pharmacy, Sungkyunkwan University, Suwon, 16419, Republic of Korea. Electronic address:
Phytochemical analysis of the methanolic extracts of Jatropha podagrica stalks and roots using liquid chromatography-mass spectrometry (LC-MS) led to the isolation of six compounds: corchoionoside C (1), isobiflorin (2), fraxin (3), hovetrichoside C (4), fraxetin (5), and corillagin (6). The isolated compounds (1-6) were tested for their cytotoxicity against MDA-MB-231 human breast cancer cells. Remarkably, compound 4 (hovetrichoside C) exhibited robust cytotoxicity against MDA-MB-231 cells, displaying an IC value of 50.
View Article and Find Full Text PDFDifferential amplification of the subtelomeric satellite DNA JcSAT1 in the genus Jatropha L. (Euphorbiaceae).
Genetica
February 2024
Laboratory of Plant Genetics and Biotechnology, Department of Genetics, Federal University of Pernambuco (UFPE), Recife, PE, 50670-423, Brazil.
Satellite DNAs (satDNAs) are highly repetitive sequences that occur in virtually all eukaryotic genomes and can undergo rapid copy number and nucleotide sequence variation among relatives. After chromosomal mapping of the satDNA JcSAT1, it was found a large accumulation at subtelomeres of Jatropha curcas (subgenus Curcas), but an absence of these monomers in J. integerrima (subgenus Jatropha).
View Article and Find Full Text PDFAntiviral Effects of Secondary Metabolites from Leaves against the Pseudotyped Virus of SARS-CoV-2 Omicron.
Plants (Basel)
November 2023
School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea.
holds a longstanding place in traditional herbal medicine, primarily utilized for addressing skin infections, acting as antipyretics, diuretics, and purgatives. In this study, our primary objective was to investigate the secondary metabolites present in leaves, with the aim of pinpointing natural compounds exhibiting potential antiviral activities. Five secondary metabolites (-), including an auronol glycoside (), two coumarins ( and ), a chromane () and a gallotannin (), were isolated from leaves.
View Article and Find Full Text PDFAntiplasmodial Activity and Phytochemical Constituents of Selected Antimalarial Plants Used by Native People in West Timor Indonesia.
Turk J Pharm Sci
February 2021
Airlangga University Faculty of Pharmacy, Department of Pharmacognosy and Phytochemistry, Surabaya, Indonesia.
Objectives: To document traditional antimalarial plants used by Tetun ethnic people in West Timor Indonesia and evaluate the antiplasmodial activity and phytochemicals of several plants that are widely used as oral medicine.
Materials And Methods: A field study to document antimalarial plants followed by laboratory works to test antiplasmodial activity and identify the phytochemical constituents of some selected plants extract were applied. The inhibitory potency of ethanolic extracts of wood, roots of , , and , whole plant of and , stem barks of , , and , and leaves of on the 3D7 strain were tested.
Two new lathyrane-type diterpenoids, jatropodagins A and B ( and ), and five known analogues (-), were isolated from the stems of . Their structures and absolute configurations were elucidated by spectroscopic data and calculated ECD analyses. The cytotoxicities of all the lathyrane-type diterpenoids (-) were evaluated against two human osteosarcoma cell lines (Saos-2 and MG-63).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!