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Is it possible for parents to endure a stillbirth? Initial experiences, perceptions and strategies: individual in-depth interviews in Sweden 2021-2023.
BMC Pregnancy Childbirth
January 2025
Department of Women's and Children's Health, Uppsala University, Uppsala, 751 85, Sweden.
Background: Stillbirth occurs at a rate of 3.0 per thousand in Sweden. However, few studies have focused on the initial experiences of parents facing a stillbirth.
View Article and Find Full Text PDFComparison between AI and human expert performance in acute pain assessment in sheep.
Sci Rep
January 2025
Department of Information Systems, University of Haifa, Haifa, Israel.
This study explores the question whether Artificial Intelligence (AI) can outperform human experts in animal pain recognition using sheep as a case study. It uses a dataset of N = 48 sheep undergoing surgery with video recordings taken before (no pain) and after (pain) surgery. Four veterinary experts used two types of pain scoring scales: the sheep facial expression scale (SFPES) and the Unesp-Botucatu composite behavioral scale (USAPS), which is the 'golden standard' in sheep pain assessment.
View Article and Find Full Text PDFThe online version of an evidence-based hand exercise programme for people with rheumatoid arthritis: An effectiveness-implementation study.
J Hand Ther
January 2025
Faculty of Health and Life Sciences, University of Exeter, Exeter, United Kingdom.
Background: The Strengthening and Stretching for Rheumatoid Arthritis of the Hand (SARAH) program is an evidence-based exercise program for adults with hand function difficulties due to rheumatoid arthritis. A self-guided online version of the program has been developed for direct access by patients.
Purpose: To evaluate the delivery of the online program in routine therapy care and its impact on clinical outcomes, before making it widely available.
Neural regulation of pain anticipation is associated with mindful behavior change in patients with anxiety or depression: A pilot study.
Psychiatry Res Neuroimaging
December 2024
Center for Mindfulness and Compassion, Cambridge Health Alliance, Cambridge, MA, USA; Harvard Medical School, Boston, USA.
Behavior change often requires overcoming discomfort or difficult emotions. Emotional dysregulation associated with anxiety or depression may prevent behavior change initiation among people managing chronic illness. Mindfulness training may catalyze chronic disease self-management by reducing experiential avoidance of aversive experiences that act as barriers to change initiation.
View Article and Find Full Text PDFA propofol binding site in the voltage sensor domain mediates inhibition of HCN1 channel activity.
Sci Adv
January 2025
Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Hyperpolarization-activated and cyclic nucleotide-gated (HCN) ion channels are members of the cyclic nucleotide-binding family and are crucial for regulating cellular automaticity in many excitable cells. HCN channel activation contributes to pain perception, and propofol, a widely used anesthetic, acts as an analgesic by inhibiting the voltage-dependent activity of HCN channels. However, the molecular determinants of propofol action on HCN channels remain unknown.
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