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Unmasking the Unusual: Cryptococcal Pericarditis in a Patient with Liver Failure - a Rare Occurrence.
Am J Case Rep
July 2024
Department of Interventional Pulmonology, TidalHealth Peninsula Regional, Salisbury, MD, USA.
BACKGROUND Cryptococcosis is an invasive fungal infection caused by Cryptococcus species complex. C. neoformans is one of the pathogenic species within the genus.
View Article and Find Full Text PDFCryptococcosis among HIV negative liver disease patients: Epidemiology, underlying conditions, antifungal susceptibility profile from tertiary care hepatobiliary center.
Indian J Med Microbiol
November 2023
Department of Microbiology, Institute of Liver and Biliary Sciences, New Delhi 110070, India. Electronic address:
Purpose: Cryptococcus neoformans is an encapsulated yeast. It is a significant pathogen among immunocompromised people with HIV & Non-HIV vulnerable populations. These conditions include cancer, corticosteroid usage, immunosuppression following sarcoidosis, organ transplantation, immunosuppressive medication, and liver cirrhosis.
View Article and Find Full Text PDFDiffuse Adrenal Gland and Pancreas Necrosis in a Patient with Disseminated Cryptococcosis-Case Report.
Life (Basel)
October 2022
Department of Pathology, Loma Linda University Medical Center, Loma Linda, CA 92354, USA.
(1) Background: Cryptococcus neoformans is mostly known for causing meningitis, with or without disseminated disease. (2) Case presentation: An immunocompromised 75-year-old gentleman presented post renal transplant with generalized weakness, altered mental status, hypoxemia, and hyponatremia, and was found to have disseminated cryptococcal infection. After an initial improvement, the patient became suddenly hypotensive, and passed away soon after.
View Article and Find Full Text PDFClinical Performance of Nanopore Targeted Sequencing for Diagnosing Infectious Diseases.
Microbiol Spectr
April 2022
Department of Clinical Laboratory, Zhongnan Hospital of Wuhan Universitygrid.49470.3egrid.413247.7, Wuhan, People's Republic of China.
The gold standard for confirming bacterial infections is culture-positive, which has a long sample-to-result turnaround time and poor sensitivity for unculturable and fastidious pathogens; therefore, it is hard to guide early, targeted antimicrobial therapy and reduce overuse of broad-spectrum antibiotics. Nanopore targeted sequencing (NTS) is reported to be advantageous in detection speed and range over culture in prior published reports. However, investigation of the clinical performance of NTS is deficient at present.
View Article and Find Full Text PDFTotal Laboratory Automation and Three Shifts Reduce Turnaround Time of Cerebrospinal Fluid Culture Results in the Chinese Clinical Microbiology Laboratory.
Front Cell Infect Microbiol
January 2022
Department of Laboratory Medicine, West China Hospital of Sichuan University, Chengdu, China.
Background: Total laboratory automation (TLA) has the potential to reduce specimen processing time, optimize workflow, and decrease turnaround time (TAT). The purpose of this research is to investigate whether the TAT of our laboratory has changed since the adoption of TLA, as well as to optimize laboratory workflow, improve laboratory testing efficiency, and provide better services of clinical diagnosis and treatment.
Materials And Methods: Laboratory data was extracted from our laboratory information system in two 6-month periods: pre-TLA (July to December 2019) and post-TLA (July to December 2020), respectively.
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