AI Article Synopsis
- The study investigates the relationship between serum levels of organochlorine pesticides (OCs) and insulin-like growth factor 1 (IGF-I) in a population from the Canary Islands.
- Women exposed to detectable levels of the DDT-metabolite p,p'-DDD had significantly lower IGF-I levels, particularly those aged 36-50.
- The research indicates a gender and age-dependent effect of OCs on IGF-I levels, suggesting these chemicals may contribute to disease development and should be addressed in public health policies.
Article Abstract
Context: Insulin-like growth factor 1 (IGF-I) and organochlorine pesticides (OCs) have been involved in the pathogenesis of several diseases like cancer, diabetes and growth disorders.
Objective And Design: The potential relationship between the serum levels of various OCs and serum IGF-I was investigated in adults (176 men and 247 women) from a representative sample of the general population of the Canary Islands (Spain).
Results: After adjustment for potential confounders, which include body mass index, age, and IGF-binding protein-3 (IGFBP-3), IGF-I levels were significantly lower in the 247 women who showed detectable levels of p,p'-DDD (a DDT-metabolite) than in women who presented non-detectable levels of this pesticide (p=0.030), specially in 36-50 years old women. A similar negative relationship was also found between IGF-I and aldrin (a non-DDT-derivative) in women (p=0.049). In the group of 176 men, aldrin seemed to exert a similar negative effect on IGF-I (p=0.046) and this effect was clearly significant in the oldest group (51-65 years) (p=0.009). A non-linear dose-response curve was observed between Total Cyclodienes Body Burden (Total Cyclodienes; sum of aldrin, dieldrin and endrin) and IGF-I in men (p=0.024). These findings suggest that OCs could modulate the IGF-system in a way that is highly influenced by gender, age and by chemical or combination of chemicals implicated. Such circumstances may contribute to the development of a number of diseases related to IGF-I and should be taken into account in public health decisions.
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| http://dx.doi.org/10.1016/j.ghir.2007.05.004 | DOI Listing |
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