AI Article Synopsis
- - The study explored how exhaled nitric oxide (FENO) relates to asthma diagnosis in adults, accounting for factors like atopy and rhinitis.
- - Results indicated that asthma significantly influenced FENO levels, with higher FENO linked to greater risk of current asthma, and a specific FENO level was found to effectively aid in asthma diagnosis.
- - The findings suggest that measuring FENO can be a useful supplementary tool alongside questionnaires for assessing asthma in the general adult population.
Article Abstract
Background: The relationship between exhaled nitric oxide (FENO) and the diagnosis of asthma in the general adult population is not completely clear.
Objectives: To investigate the association between FENO and asthma, after controlling for atopy and rhinitis, in a general population sample of adults (mean age 43 years).
Methods: The cohort of subjects was a sample of subjects who gave their consent to participate in the European Community Respiratory Health Survey II study.
Results: Atopy, rhinitis and current asthma were positively and current smoking was negatively associated with FENO. Multivariate analysis showed that asthma had a significant predictive effect on FENO (beta = 0.53; 95% CI 0.21-0.84, p = 0.001), and the increase in FENO was significantly associated with the risk of current asthma (OR = 1.07, 95% CI 1.00-1.14) by the logistic regression model. Receiver-operator characteristic curve showed that FENO >or=18.5 ppb had the best combination of sensitivity (69.2%) and specificity (71%), with a positive predictive value of 24% and a negative predictive value of 95%, for the diagnosis of asthma.
Conclusions: Measuring FENO seems to be suitable as an adjunct to questionnaire in the evaluation of asthma in the general population.
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| http://dx.doi.org/10.1159/000104852 | DOI Listing |
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