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Biphasic glucose-stimulated insulin secretion over decades: a journey from measurements and modeling to mechanistic insights.
Life Metab
February 2025
New Cornerstone Science Laboratory, State Key Laboratory of Membrane Biology, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, National Biomedical Imaging Center, The Beijing Laboratory of Biomedical Imaging, Peking-Tsinghua Center for Life Sciences, School of Future Technology, Peking University, Beijing 100871, China.
Glucose-stimulated insulin release from pancreatic β-cells is critical for maintaining blood glucose homeostasis. An abrupt increase in blood glucose concentration evokes a rapid and transient rise in insulin secretion followed by a prolonged, slower phase. A diminished first phase is one of the earliest indicators of β-cell dysfunction in individuals predisposed to develop type 2 diabetes.
View Article and Find Full Text PDFAn atlas of glucose uptake across the entire human body as measured by the total-body PET/CT scanner: a pilot study.
Life Metab
October 2022
Department of Radiology, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, Shandong 271016, China.
Glucose uptake differs in organs and tissues across the human body. To date, however, there has been no single atlas providing detailed glucose uptake profiles across the entire human body. Therefore, we aimed to generate a detailed profile of glucose uptake across the entire human body using the uEXPLORER positron emission tomography/computed tomography scanner, which offers the opportunity to collect glucose metabolic imaging quickly and simultaneously in all sites of the body.
View Article and Find Full Text PDFExploring the Association Between Triglyceride-Glucose Indices and Their Derivatives With Obstructive Sleep Apnea: Insights From the National Health and Nutrition Examination Survey.
Nat Sci Sleep
January 2025
Kunshan Hospital of Traditional Chinese Medicine, Kunshan City, Suzhou, Jiangsu Province, People's Republic of China.
Background: Simple and affordable methods for evaluating Insulin Resistance (IR) have been suggested, such as the Triglyceride-Glucose (TyG) index and its variants, including the TyG-Body Mass Index (TyG-BMI), TyG-Waist Circumference (TyG-WC), and TyG-Waist-to-Height Ratio (TyG-WHtR). The aim of this study is to investigate the relationship between these TyG-related indices, which measure IR, and Obstructive Sleep Apnea (OSA).
Methods: This study analyzed NHANES data from 2007-2008, 2015-2016, and 2017-2020.
Gestational weight gain patterns as predictors of cesarean deliveries in women diagnosed with gestational diabetes mellitus.
BMC Pregnancy Childbirth
January 2025
Obstetrician and Gynecologist, Department of Obstetrics and Gynecology, Cheng-Hsin General Hospital, Taipei, Taiwan.
Background: Obesity and excessive gestational weight gain (GWG) have been linked to an increased risk of cesarean section. However, existing literature primarily focuses on weight gain during individual trimesters, lacking a comprehensive assessment of GWG trajectories across all three trimesters. This study aimed to investigate the impact of pre-pregnancy BMI and changes in GWG trajectories from the first to the third trimester on cesarean section in women with confirmed gestational diabetes mellitus (GDM).
View Article and Find Full Text PDFAssociation between elevated glycosylated hemoglobin levels and hypertension among US adults: NHANES 2011-2018.
BMC Cardiovasc Disord
January 2025
Department of Laboratory, Kunming Third people's hospital, 319 Wujing Road, Kunming City, Yunnan Province, 650041, P.R. China.
Introduction: Hypertension (HTN) and diabetes frequently coexist. This study aims to elucidate the associations between HTN and glycosylated hemoglobin (HbA1c), as well as the connections between distinct forms of HTN and HbA1c.
Methods: We collected data from National Health and Nutrition Examination Survey (NHANES) 2011-2018 in this study, including anthropometric tests and biochemical measures.
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