Open partial laryngectomies include a broad variety of vertical or horizontal partial or supracricoid laryngectomies. Especially in Germany the excellent results of the transoral approach in combination with the CO2 laser surgery radically have diminished the indications of the open surgical techniques for laryngeal cancer staged cT1-2. In patients with laryngeal cancer staged cT3 the role of open organ-preservation surgery remains to be defined in the context of extended treatment options for endolaryngeal CO2 laser surgery and conservative larynx-preservation approaches with concurrent chemoradiation or induction chemotherapy followed by radiation therapy. With regard to the reviewed literature this manuscript will discuss current indications and future roles of open partial laryngectomies with special emphasis given to the supracricoid laryngectomies.
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http://dx.doi.org/10.1055/s-2007-966535 | DOI Listing |
Eur J Med Chem
December 2024
School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China; State Key Laboratory on Technologies for Chinese Medicine Pharmaceutical Process Control and Intelligent Manufacture, Nanjing University of Chinese Medicine, Nanjing 210023, China. Electronic address:
Myeloid cell leukemia-1 (MCL-1), a key anti-apoptotic protein within the BCL-2 family, is essential in regulating cell survival, particularly in cancer, where its overexpression is often linked to therapeutic resistance. This review begins with an overview of BCL-2-mediated apoptosis, highlighting the pivotal role of MCL-1 in cellular homeostasis. We then focus on the structure and function of MCL-1, elucidating how its unique structural features contribute to its function and interaction with pro-apoptotic proteins.
View Article and Find Full Text PDFJ Pharm Biomed Anal
December 2024
GICAPC Research Group, Department of Analytical Chemistry, University of Valencia, Burjassot, Valencia 46100, Spain. Electronic address:
This review article brings together two of the current hot-spots in the field of analytical chemistry, and more specifically in the sample preparation stage: the use of dispersive microextraction techniques, and the analysis of saliva. Due to saliva collection is minimally invasive, it is increasingly being considered in bioanalysis. Moreover, bioanalysis is routine and agglutinates a high number of samples demanding for fast results, thus high-throughput assays are highly required.
View Article and Find Full Text PDFThe rapid advances in genomics over the last decade have come to fruition amid intense public discussions of justice in medicine and health care. While much emphasis has been placed on increasing diversity in genomics research participation, an overly narrow focus on recruitment eschews recognition of the disparities in health care that will ultimately shape access to the benefits of genomic medicine. In this essay, we suggest that achieving a just genomics, both now and in the future, requires an explicit ELSI of translation-normative and pragmatic scholarship that embraces the interconnectedness of research and clinical care and centers the obligations of researchers, institutions, and funders to mitigate inequities throughout the translational pipeline.
View Article and Find Full Text PDFWound Repair Regen
December 2024
Department of Biomedical Engineering, University of Alberta, Canada.
Burns and chronic wounds present significant challenges in wound management due to risks of infection, excessive inflammation, and prolonged healing. Silver-based treatments have long been central to burn care, but limitations have prompted the exploration of nanocrystalline silver as an alternative, with its nanoscale properties offering distinct benefits. This paper reviews the structure, properties, mechanisms of action, and clinical applications of nanocrystalline silver in burn and general wound management, with particular emphasis on how wound healing processes inform the application of these dressings.
View Article and Find Full Text PDFLipids Health Dis
December 2024
Department of Orthopedic Surgery, Chungnam National University School of Medicine, Daejeon, Republic of Korea.
Background: Life's Simple 7 (LS7), developed by the American Heart Association, addresses seven key health behaviors and relationship factors. Although LS7 has been studied in relation to various chronic diseases, its association with arthritis remains unclear. This study seeks to investigate the association between LS7 and arthritis, with particular emphasis on the mediating role of body fat percentage (BFP).
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