Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1038/nn0707-801 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Neurophysiological assessment of cortical motor function: A direct comparison of methodologies.
Clin Neurophysiol
December 2024
Neuroscience Research Australia, 139 Barker Street, Randwick, 2031, Sydney, Australia; University of NSW and Department of Neurology, Prince of Wales Hospital, South Eastern Sydney Area Health Service, Sydney, Australia.
Objective: Assessment of cortical function with threshold tracking transcranial magnetic stimulation (TT-TMS) has developed as a biomarker to inform disease pathophysiology, particularly in neurodegenerative disease and dementia. At present, a fully integrated testing system does not exist. To advance clinical utility, and to streamline software design to integrate with diagnostic approaches in an outpatient setting, the present series of studies assessed the effects of altering diagnostic paradigms to measure interstimulus interval (ISI) including serial ascending [T-SICIs] and parallel [T-SICIp] methodologies as measures of cortical motor function (the MagXite software).
View Article and Find Full Text PDFMotor cortex excitability in restless legs syndrome: A systematic review and insights into pathophysiology via transcranial magnetic stimulation.
Sleep Med Rev
November 2024
Department of Medicine and Neurology, Hi-Tech Medical College and Hospital, Utkal University, Bhubaneswar, 752101, Odisha, India. Electronic address:
Article Synopsis
- - Restless Legs Syndrome (RLS) is a neurological disorder with unclear underlying mechanisms, and this study reviews various research on motor cortex activity in RLS patients using transcranial magnetic stimulation (TMS).
- - Out of several studies reviewed, 21 met the criteria, revealing a common pattern of reduced short-interval intracortical inhibition, indicating issues with GABAergic activity in RLS patients, despite differences in research methods.
- - The research suggests that RLS symptoms may arise from different levels of a complex neural network, indicating potential for new diagnostic tools and treatment approaches, but further studies are needed for validation.
Holographic Ultrasound Modulates Neural Activity in a 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Mouse Model of Parkinson's Disease.
Research (Wash D C)
November 2024
Paul C. Lauterbur Research Center for Biomedical Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Ultrasound (US) has emerged as a noninvasive neurostimulation method for motor control in Parkinson's disease (PD). Previous in vivo US neuromodulation studies for PD were single-target stimulation. However, the motor symptoms of PD are linked with neural circuit dysfunction, and multi-target stimulation is conducted in clinical treatment for PD.
View Article and Find Full Text PDFEffect of the magnitude of abrupt change in sound pressure on the magnitude and phase synchrony of 40-Hz auditory steady state response.
Neuroscience
November 2024
Department of Neuropsychiatry, Mie University Graduate School of Medicine, Tsu 514-8507, Japan. Electronic address:
A periodic sound with a fixed inter-stimulus interval elicits an auditory steady-state response (ASSR). An abrupt change in a continuous sound is known to affect the brain's ongoing neural oscillatory activity, but the underlying mechanism has not been fully clarified. We investigated whether and how an abrupt change in sound intensity affects the ASSR.
View Article and Find Full Text PDFSomatosensory temporal discrimination analysis reveals impaired processing in amyotrophic lateral sclerosis.
Muscle Nerve
December 2024
Department of Neurology, Section of Clinical Neurophysiology, Faculty of Medicine, Gazi University, Ankara, Turkey.
Introduction/aims: While amyotrophic lateral sclerosis (ALS) is primarily characterized as a motor system disorder, there is a growing body of evidence indicating sensory involvement. This study aimed to examine the hypothesis that somatosensory processing is impaired in ALS.
Methods: Study participants were ALS patients followed at the Neuromuscular Outpatient Unit, as well as healthy volunteers, from March 2021 to July 2023.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!