Background: Indocyanine green (ICG) is a fluorescent marker that is excited by rays at a wavelength of 768 nm to emit fluorescence at a wavelength of 807 nm in the infrared (IR) range. We developed an IR fluorescence endoscope (IRFE) to observe superficial gastric tumors and assessed its clinical usefulness.
Objective: To evaluate the clinical usefulness of an IRFE for the assessment of superficial gastric tumors.
Design: An observational study.
Setting: University hospital.
Interventions: Newly developed IRFE.
Patients: Thirty patients with gastric tumors were enrolled in this study, and their lesions were subjected to endoscopic submucosal dissection (ESD), or laparoscopic gastrectomy after observation with the IRFE.
Methods: Gastric lesions were subjected to conventional observation, followed by IR fluorescence observation before and after intravenous ICG (0.01 mg/kg) injection.
Main Outcome Measurements: The relationship between the positive fluorescence and invasivity of each tumor.
Results: Fluorescence was positive in 8 of 10 gastric cancers with submucosal invasion (80%) and 1 of 20 adenomas or intramucosal gastric cancers (5%); the difference was statistically significant (P<.01).
Conclusion: IRFE is a useful diagnostic tool for estimating the invasivity of gastric tumors.
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http://dx.doi.org/10.1016/j.gie.2007.01.009 | DOI Listing |
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