One hundred and six patients with culture-positive bacterial meningitis were admitted to Sulemania Children's Hospital, Riyadh, from February 1985 to July 1990. The most common organisms causing meningitis in children older than 1 month were Hemophilus influenzae type b (N = 61), Streptococcus pneumoniae (N = 19), and Neisseria meningitidis (N = 14). Among neonates, the most common organism causing meningitis was Group B beta-hemolytic Streptococcus (N = 4). Of the cases of Hemophilus influenzae, 4.9% were resistant to both ampicillin and chloramphenicol. Forty-two patients were pretreated with antibiotics. The mortality rate was 2.8%. We describe the clinical and laboratory findings in these patients. We also discuss the implications of our findings in relation to the choice of antibiotics.
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http://dx.doi.org/10.5144/0256-4947.1991.628 | DOI Listing |
Front Immunol
January 2025
Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Background And Objective: Neurobrucellosis is a rare neurological disorder characterized by diverse clinical manifestations. Although several relevant cases were reported, our understanding of this disorder is limited. In this study, we presented the clinical and imaging characteristics of four cases of neurobrucellosis.
View Article and Find Full Text PDFFront Med (Lausanne)
January 2025
Department of Neurology, Guangxi University of Science and Technology First Affiliated Hospital, Liuzhou, China.
Purpose: This study aims to explore the underlying causes, diagnostic strategies, and treatment approaches of trauma-induced invasive syndrome (KPIS) through a rare case report. By highlighting the role of trauma as a potential trigger for KPIS, particularly in high-risk populations such as individuals with diabetes, this study seeks to provide valuable insights for improving clinical outcomes and promoting public health awareness.
Background: invasive syndrome is a multi-organ infectious disease commonly associated with complications such as liver abscess, lung abscess, endophthalmitis, and purulent meningitis, with high mortality and disability rates.
Front Cell Infect Microbiol
January 2025
Department of Respiratory and Critical Care Medicine, The Second Hospital of Jilin University, Changchun, Jilin, China.
() is a Gram-positive bacterium commonly colonizing the skin and mucosa in healthy individuals and hospitalized patients. Traditionally regarded as a contaminant, is now increasingly recognized as a potential cause of clinical infections, especially after the coronavirus disease pandemic. It has emerged as a pathogen implicated in severe infections, including pneumonia, bacteremia, meningitis, artificial joint infections, abdominal infections, and endocarditis.
View Article and Find Full Text PDFClin Transl Sci
January 2025
Service de Pharmacie Clinique, CHU de Bordeaux, Hôpital Pellegrin, Bordeaux, France.
Penetration of antimicrobial treatments into the cerebrospinal fluid is essential to successfully treat infections of the central nervous system. This penetration is hindered by different barriers, including the blood-brain barrier, which is the most impermeable. However, inflammation may lead to structural alterations of these barriers, modifying their permeability.
View Article and Find Full Text PDFBMJ Case Rep
January 2025
Neurology Department, Singapore General Hospital, Singapore.
A woman in her 30s presented with sudden onset right-sided weakness, speech difficulties and transient loss of consciousness. She had a medical history of migraine, hypothyroidism and cervical lymphadenopathy. On examination, her National Institutes of Health Stroke Scale (NIHSS) score was 8 due to dense right-sided hemiparesis.
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