AI Article Synopsis
- The study focuses on patients with limited ophthalmic Wegener granulomatosis (WG), examining their clinical symptoms and biopsy results.
- Thirteen patients exhibited eye-related inflammation but did not show significant lung or kidney issues; some had sinus involvement.
- Histopathological findings, including specific granulomas and immune cell presence, along with positive ANCA tests, support the diagnosis of limited ophthalmic WG despite minimal systemic disease.
Article Abstract
Purpose: To describe the clinical and histopathologic finding of very limited ophthalmic Wegener granulomatosis (WG).
Methods: Thirteen patients with scleritis, orbitopathy, episcleritis, and panuveitis were studied. They presented without evidence of lung or kidney disease, though eight had sinus involvement. We reviewed the biopsies for histopathologic findings consistent with WG, and tested for antineutrophil cytoplasmic antibodies antineutrophil cytoplasmic antibody (ANCA).
Results: WG was suggested by granulomatous foci, collagen necrosis, neutrophils/nuclear dust, plasma cells and infiltrating eosinophils. Granular degeneration of the interstitial collagen; mummification of the collagen with disappearance of fibroblastic nuclei; and a polymorphous infiltrate exhibiting plasma cells, lymphocytes, neutrophils, and eosinophils within the epithelioid granulomas should suggest the diagnosis. ANCA test results supported the diagnosis of WG in all cases.
Conclusion: The described histologic characteristics are highly suggestive of WG. These findings along with clinical or laboratory findings, allow the diagnosis of very limited ophthalmic WG in the absence of systemic involvement.
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| http://dx.doi.org/10.1007/s10792-007-9109-y | DOI Listing |
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