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Identification of key gene signatures for predicting chemo-immunotherapy efficacy in extensive-stage small-cell lung cancer using machine learning.
Lung Cancer
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Internal Medicine III, Wakayama Medical University, Wakayama, Japan.
Objectives: The lack of definitive biomarkers presents a significant challenge for chemo-immunotherapy in extensive-stage small-cell lung cancer (ES-SCLC). We aimed to identify key genes associated with chemo-immunotherapy efficacy in ES-SCLC through comprehensive gene expression analysis using machine learning (ML).
Methods: A prospective multicenter cohort of patients with ES-SCLC who received first-line chemo-immunotherapy was analyzed.
Status of Sepsis Care in European Hospitals: Results from an International Cross-Sectional Survey.
Am J Respir Crit Care Med
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University of Medicine and Pharmacy Carol Davila Bucharest, Bucuresti, Romania.
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Department of Anesthesiology and Critical Care, CHU Rouen, Rouen, France.
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View Article and Find Full Text PDFTwenty-Five Years of Evolution and Hurdles in Electronic Health Records and Interoperability in Medical Research: Comprehensive Review.
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Chronic Disease Epidemiology, Population and Public Health, Pennington Biomedical Research Center, Baton Rouge, LA, United States.
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Objective: This study aimed to summarize the evolution of secondary use of EHRs and their interoperability in medical research over the past 25 years.
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Business Venturing in Regulated Markets-Taxonomy and Archetypes of Digital Health Business Models in the European Union: Mixed Methods Descriptive and Exploratory Study.
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Institute for Entrepreneurship, Technology Management and Innovation (EnTechnon), Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany.
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