AI Article Synopsis
- A group of benzodiazepines and benzazepinones was created to test their ability to block sodium channels.
- One specific compound, identified as compound 47 from the benzazepinone group, showed strong and selective blocking effects on a particular sodium channel (hNa(v)1.7).
- This compound also proved to be effective when taken orally in a rat model that simulates neuropathic pain.
Article Abstract
A series of benzodiazepines and benzazepinones were synthesized and evaluated as potential sodium channel blockers in a functional, membrane potential-based assay. One member of the benzazepinone series, compound 47, displayed potent, state-dependent block of hNa(v)1.7, and was orally efficacious in a rat model of neuropathic pain.
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| http://dx.doi.org/10.1016/j.bmcl.2007.05.076 | DOI Listing |
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