AI Article Synopsis
Article Abstract
Since fluoroquinolones have generated much interest because of their excellent in vitro and in vivo activity, their pharmacokinetic propertiesm oral dosing and intracellular penetration, we tested the susceptibility of 146 recent clinical isolated of Brucella melitensis agaist eight 4-quinolone drugs and five conventional drugs. The drugs tested included ciprofloxacin, norfloxacin, temafloxacin, sparfloxacin, fleroxacin, pefloxacin, lomefloxacin, CI-960, tetracycline, gentamicin, streptomycin rifampicin and trimethoprim-sulfamethoxazole. All the isolates were susceptible to the eight quinolones tested, with an MIC-90 ranging between 0.12 mg/L to 2.0 mg/L depending on the drug. Lowest MCIs were observed with CI-960 and highest temafloxacin and sparfloxacin. One isolate which had developed resistance to ciprofloxacin while the patient was being treated with this drug exhibited cross-resistance to all the members of the family.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.5144/0256-4947.1993.37 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Genetic diversity atlas of Brucella melitensis strains from Sichuan Province, China.
BMC Microbiol
January 2025
National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China.
Human brucellosis is a re-emerging disease in Sichuan Province, China. In this study, bacteriology, conventional bio-typing, multi-locus sequence typing (MLST), and multiple locus variable-number tandem repeat analysis (MLVA) were applied to preliminarily characterize the strains in terms of genetic diversity and epidemiological links. A total of 101 Brucella strains were isolated from 16 cities (autonomous prefectures) from 2014 to 2021, and all of the strains were identified as Brucella melitensis bv.
View Article and Find Full Text PDFMolecular and serological investigation of Brucella species in kennel and farm dogs in Iran.
Acta Trop
January 2025
Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahid Bahonar University of Kerman, Kerman, Iran.
Introduction: Brucellosis is still a significant emerging threat to public health, as it can infect humans, wild, domestic animals, and livestock. Hence, the current study aims to determine the frequency of canine brucellosis (CB), its relationship with clinical findings and reproductive disorders in kennel and farm dogs, and its importance on public health.
Materials And Methods: From January 2022 to December 2023, a total of 150 blood samples were taken from 100 adult dogs in breeding kennels and 50 shepherd dogs in breeding farms in Kerman, Iran.
In silico MLVA Analysis of Brucella melitensis from Human and Livestock in Iran.
Curr Microbiol
January 2025
Agricultural Research, Education and Extension Organization (AREEO), Razi Vaccine and Serum Research Institute (RVSRI), Karaj, Iran.
Brucellosis, a zoonotic disease caused by Brucella spp. globally, is of great significance not only to livestock but also to public health. The most significant of the twelve species is Brucella melitensis.
View Article and Find Full Text PDFDetection and Molecular Diversity of in Pastoral Livestock in North-Eastern Ethiopia.
Pathogens
December 2024
Institute of Biotechnology, Addis Ababa University, Addis Ababa P.O. Box 1176, Ethiopia.
Brucellosis is a neglected zoonotic disease affecting livestock and humans that remains endemic in Ethiopia. Despite its prevalence, only a few studies have identified species circulating in livestock in the country. This study aimed to determine the species responsible for infections in livestock in the Afar region of Ethiopia and characterize the isolates using whole-genome single nucleotide polymorphism (wgSNP) analysis and in silico multi-locus sequence typing (MLST).
View Article and Find Full Text PDFTrue prevalence and spatial distribution of antibodies to Brucella spp. in goat populations in Hubei Province, People's Republic of China: Progress toward disease elimination.
Prev Vet Med
December 2024
National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China; College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China; Hubei International Scientific and Technological Cooperation Base of Veterinary Epidemiology, Huazhong Agricultural University, Wuhan, China; School of Veterinary Medicine, Murdoch University, Perth, WA, Australia. Electronic address:
Caprine brucellosis, mainly caused by Brucella melitensis, remains a significant zoonotic threat worldwide, affecting animal productivity, welfare, and public health. This study aimed to estimate the true prevalence (TP) and spatial distribution of antibodies to Brucella spp. among goat populations in Hubei Province, China.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!