AI Article Synopsis

  • A study of 50 children with Down syndrome revealed that 14% tested positive for antithyroid antibodies, indicating a potential autoimmune response.
  • Six individuals had antimicrosomal antibodies and three had both antimicrosomal and antithyroglobulin antibodies, while none tested positive for antithyroglobulin alone.
  • Three children in the Down syndrome group were diagnosed with hypothyroidism, highlighting the need for regular screening for thyroid issues in this population.

Article Abstract

Fifty children (ages seven months to nine years) with Down syndrome compared with age and sex matched controls were tested for antithyroid antibodies. Seven (14%) of the Down group were found to b seropositive; six (12%) for antimicrosomal antibodies; three for both antimicrosomal and antithyroglobulin; none was positive for antithyroglobulin alone. All the control group were seronegative and had no clinical evidence of thyroid disease. Three (6%) of the Down group had hypothyroidism, two due to autoimmune thyroiditis and one had disease. Thyroid dysfunction was not previously suspected in the two symptomatic children. In view of our findings, recommendations are made to regularly screen these children for autoantibdies and evidence of thyroid dysfuntion.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363516PMC
http://dx.doi.org/10.5144/0256-4947.1994.283DOI Listing

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