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| http://dx.doi.org/10.1136/adc.2006.108167 | DOI Listing |
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The highly rugged yet navigable regulatory landscape of the bacterial transcription factor TetR.
Nat Commun
December 2024
Department of Evolutionary Biology and Environmental Studies, University of Zurich, Winterthurerstrasse 190, Zurich, CH-8057, Switzerland.
Transcription factor binding sites (TFBSs) are important sources of evolutionary innovations. Understanding how evolution navigates the sequence space of such sites can be achieved by mapping TFBS adaptive landscapes. In such a landscape, an individual location corresponds to a TFBS bound by a transcription factor.
View Article and Find Full Text PDFMassive hydropyonephrosis on pediatric patient: A case report of management and source control.
Int J Surg Case Rep
December 2024
Department of Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand; Department of Biomedical Science, Faculty of Medicine, Universitas Surabaya, Indonesia.
Introduction And Importance: Dilation and stretching of the collecting system of the kidney due to obstruction of urine flow is called hydronephrosis. This case may be accompanied by the presence of pus known as pyonephrosis. This case report reporting massive pyonephrosis in pediatrics related to management and source of control.
View Article and Find Full Text PDFGram-negative bacteria-driven increase of cytosolic phospholipase A2 leads to activation of Kupffer cells.
Cell Mol Life Sci
December 2024
Department of Internal Medicine and Gastroenterology, Internistisches Klinikum München Süd, Am Isarkanal 36, Munich, Germany.
Article Synopsis
- Bacterial infections are a major issue for patients with cirrhosis, impacting their overall health due to their role in increasing morbidity and mortality.
- This study investigates the role of cytosolic phospholipase A2 (cPLA2) in the activation of human Kupffer cells (HKCs) by gram-negative bacteria, specifically looking at how E. coli influences HKC activation through specific signaling pathways.
- The findings suggest that cPLA2 is crucial for HKC activation in response to E. coli, linking its activity to the regulation by transcription factors STAT3 and RelB via the ERK and non-canonical NF-κB signaling pathways, potentially paving the way for therapeutic strategies in managing bacterial infections in cirrhotic patients
Deciphering regulatory architectures of bacterial promoters from synthetic expression patterns.
PLoS Comput Biol
December 2024
Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, United States of America.
For the vast majority of genes in sequenced genomes, there is limited understanding of how they are regulated. Without such knowledge, it is not possible to perform a quantitative theory-experiment dialogue on how such genes give rise to physiological and evolutionary adaptation. One category of high-throughput experiments used to understand the sequence-phenotype relationship of the transcriptome is massively parallel reporter assays (MPRAs).
View Article and Find Full Text PDFGastrointestinal jumbo phages possess independent synthesis and utilization systems of NAD.
Microbiome
December 2024
College of Life Sciences, Shihezi University, Shihezi, Xinjiang, 832003, China.
Article Synopsis
- Jumbo phages are large viruses with genomes over 200 kbp, and little is known about their life cycle and unique reproductive genes.
- Researchers assembled 668 high-quality jumbo phage genomes from 955 samples of various animal species and identified the largest known phage genome at 716 kbp, revealing they can synthesize NAD and contain numerous NAD-consuming enzymes.
- The study highlights the widespread presence of NAD-jumbo phages in different ecosystems, emphasizing the need for further research on their ecological roles and survival strategies.
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