Importance of body surface potential field representation fidelity: analysis of beat-to-beat repolarization measurements.

Objective: According to previous studies, the complex substrate of malignant arrhythmias needs a detailed spatio-temporal noninvasive characterization of low-amplitude dynamic changes in beat-to-beat cardiac repolarization.

Methods: Body surface potential map (BSPM) records were taken on 14 healthy male and female subjects (age 20-80 years) and on 6 ventricular arrhythmia patients, 4 of them with implanted cardioverter defibrillators (ICD). Records were taken continuously, for 5 minutes, in resting, supine position. Beat-to-beat QRST integral maps, Karhunen-Loéve coefficient time-series (KLi, i=1-12), RR and nondipolarity index (NDI) time-series were computed.

Results: The first order statistical properties of the spatio-temporal variability of subsequent QRST integral maps were characterized by the box and whiskers plot of their KLi components. The SD2/M2 (KLi amplitude variance/mean signal energy) values of the QRST integral maps in the normal group ranged between 0.0057 and 0.008 (i.e. 0.075=or
Conclusions: Beat-to-beat dynamics of white noise components of high resolution BSPMs are able to stratify arrhythmia vulnerability. The temporal distribution of extreme NDI spike formations is random; the frequency is associated with the relative KL component noise levels.