Objective: To investigate the characteristics of 24-hr ambulatory electrocardiography (DCG) of children with myocarditis and to study the clinical value of DCG in the diagnosis of childhood myocarditis.
Methods: 24-hr DCG findings, including abnormal DCG rate, and number, grade and distribution of ventricular premature beat (PVC), as well as heart rate variability, from 59 children with myocarditis were retrospectively reviewed and compared with those detected in 41 children without heart disease.
Results: 86.4% of patients with myocarditis showed abnormal DCG, and compound arrhythmia was commonly seen, but only 46.3% showed abnormal DCG (P < 0.01) and single arrhythmia was predominant in the control group. The number and grade of PVC/24 hrs were not significantly different between the two groups. Compared with the control group, the average pattern PVC was predominant in the myocarditis group (84.6% vs 48.7%; P < 0.05). Monopeak pattern PVC was mostly seen (64.4%), followed by multiple-peak pattern (25.4%) and bi-peak pattern (8.4%) in the myocarditis group, which were significantly different from the control group: monopeak pattern 53.6%, bi-peak pattern 36.6% and multiple-peak pattern 7.3% (P < 0.01).
Conclusions: The 24-hr DCG characteristics of children with myocarditis are different from the normal controls, suggesting 24-hr DCG monitoring is useful to the diagnosis of childhood myocaditis.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Safety and efficacy of immune checkpoint inhibitors in patients with pre-treatment reduced left ventricular function.
Cardiooncology
January 2025
Division of Cardiology, Tel Aviv Sourasky medical Center, Tel Aviv, Israel.
Aims: Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment outcomes. However, the response varies across different populations, and their use may lead to life-threatening cardiovascular (CV) events. While pre-treatment reduced left ventricular ejection fraction (LVEF) is considered a marker for high-risk cardiotoxicity and a contraindication for anthracycline and HER2-targeted therapies, there is limited evidence on the safety and efficacy of ICIs therapy in patients presenting with pre-treatment reduced LVEF.
View Article and Find Full Text PDFInflammatory Heart Disease in Multisystem Inflammatory Syndrome.
Curr Cardiol Rep
January 2025
Robert M. Berne Cardiovascular Research Center, and Department of Medicine, DivisionofCardiovascularMedicine,HeartandVascularCenter, University of Virginia, Charlottesville, VA, USA.
Purposeof The Review: In this review article, we aim to provide an overview of the pathophysiology, the clinical features, the therapeutic management and prognosis of patients affected by Multisystemic inflammatory syndrome (MIS) with cardiac involvement, focusing on myocarditis and pericarditis.
Recent Findings: MIS is a multiorgan hyperinflammatory condition due to a cytokine storm following (within 4-12 weeks) SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) infection. First described in children, it also affects young adults without comorbidities, predominantly males with highly heterogeneous clinical manifestations, including cardiac involvement.
Evolution of Theories on Doxorubicin-Induced Late Cardiotoxicity-Role of Topoisomerase.
Int J Mol Sci
December 2024
Department of Pneumology, Oncology and Allergology, Medical University of Lublin, Jaczewskiego 8, 20-090 Lublin, Poland.
Doxorubicin (DOX) has been widely used as a cytotoxic chemotherapeutic. However, DOX has a number of side effects, such as myelotoxicity or gonadotoxicity, the most dangerous of which is cardiotoxicity. Cardiotoxicity can manifest as cardiac arrhythmias, myocarditis, and pericarditis; life-threatening late cardiotoxicity can result in heart failure months or years after the completion of chemotherapy.
View Article and Find Full Text PDFLife-Threatening Respiratory Complications in Two Young Children with Extreme Obesity.
Children (Basel)
December 2024
Department of Pediatrics, Endocrinology, Diabetology, Metabolic Diseases and Cardiology, University Clinical Hospital No. 1, Pomeranian Medical University in Szczecin, 71-215 Szczecin, Poland.
Background/objectives: Obesity is a chronic disease characterized by pathological accumulation of adipose tissue. The exponentially increasing number of children with severe obesity draws attention to the tragic consequences of the lack of, or inadequate treatment of, obesity in this age group. This article aims to present ways of preventing obesity and ways of treating its complications in order to reduce the risk of the life-threatening problems caused by it.
View Article and Find Full Text PDFOutbreak of Acute Fulminant Myocarditis in Children in Campania Region, Italy: A Case Series.
Children (Basel)
November 2024
Pediatric Emergency Unit, Santobono-Pausilipon Children's Hospital, 80129 Naples, Italy.
Acute fulminant myocarditis is a rare event in children, accounting for about 10% of all cases of acute myocarditis. Its lack of specific onset patterns and unpredictable evolution make diagnosis and prompt treatment challenging. We observed six cases of fulminant myocarditis admitted to our Pediatric Emergency Unit (Campania region, Sothern Italy) within a very short timeframe (50 days, from July to September 2024).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!