The bronchoscopic investigation was performed in 15 467 patients treated for respiratory tuberculosis in the Central Military Clinical Tuberculous Hospital N 4 for the last 20 years. The bronchial tuberculosis was revealed in 1315 (8,5%) patients. Among them the tumoral process was detected in 113 (8,6%), including the central cancer--in 84 patients,and the peripheral cancer--in 29. According to initial diagnosis these patients were distributed in the following way: the infiltrative pulmonary tuberculosis was in 70 (1,9%), the exudative pleurisy-- in 14 (12,4%), the tuberculosis of intrathoracic lymph nodes-- in 8 (7,1%), the tuberculoma--in 8 (7,1%), the condition after operation for tuberculosis--in 5 (4,5%), the cavernous tuberculosis--in 3 (2,6%), the cirrhotic tuberculosis--in 3 (2,5%) and the pneumonia--in 2 (1,8%). The biological material was obtained with the use of direct biopsy, brush biopsy, guided catheter-biopsy and bronchoalveolar lavage. All bronchological findings were confirmed by cytological and histological examinations.
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PLoS One
January 2025
Molecular Biophysics Unit, Indian Institute of Science, Bengaluru, Karnataka, India.
Pulmonology
December 2025
Department of Allergology, Institute of Allergology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Rhinitis is a common comorbidity in patients with asthma. However, the frequency of underreported rhinitis in asthma is not known. In this study, we aimed to assess the characteristics of patients with self-reported asthma and no self-reported rhinitis, as well as the extent of the underreporting of rhinitis.
View Article and Find Full Text PDFLangmuir
January 2025
Center for Condensed Matter Theory, Department of Physics, Indian Institute of Science (IISc), Bangalore 560012, India.
The enduring pathogenicity of can be attributed to its lipid-rich cell wall, with mycolic acids (MAs) being a significant constituent. Different MAs' fluidity and structural adaptability within the bacterial cell envelope significantly influence their physicochemical properties, operational capabilities, and pathogenic potential. Therefore, an accurate conformational representation of various MAs in aqueous media can provide insights into their potential role within the intricate structure of the bacterial cell wall.
View Article and Find Full Text PDFJ Bacteriol
January 2025
Interfaculty Institute of Microbiology and Infection Medicine Tübingen (IMIT), Department of Microbiology and Biotechnology, University of Tübingen, Tübingen, Baden-Württemberg, Germany.
Unlabelled: is well adapted to survive and persist in the infected host, escaping the host's immune response. Since polyamines such as spermine, which are synthesized by infected macrophages, are able to inhibit the growth of , the pathogen needs strategies to cope with these toxic metabolites. The actinomycete , a close relative of makes use of a gamma-glutamylation pathway to functionally neutralize spermine.
View Article and Find Full Text PDFCurr Opin Pediatr
January 2025
Sydney Infectious Diseases Institute (Sydney ID), University of Sydney, Sydney, New South Wales, Australia.
Purpose Of Review: Life on earth, as we know it, is changing. The likelihood of more frequent pandemics and disease outbreaks is something that current global healthcare infrastructure is ill equipped to navigate. Human activity is forcing our planet into a new geologic epoch, the Anthropocene, which is typified by increased uncertainty resulting from human disruption of earth's life-giving ecosystems.
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