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Pilomatrix carcinoma unveiled: a systematic review of clinical characteristics, pathogenesis, diagnostic puzzles, and management strategies.
Arch Dermatol Res
January 2025
Premier Dermatology, Ashburn, VA, USA.
Pilomatrix carcinoma (PC) is a rare malignant adnexal tumor originating from follicular matrix cells primarily impacting Caucasian males. This review provides a comprehensive analysis of scientific literature on PC through an exploration of 206 cases reported between 1980 and 2024. We discuss the epidemiology, clinical presentation, histopathology, and diagnostic challenges of PC, and explore various treatment methods for this rare malignancy as well as their associated outcomes.
View Article and Find Full Text PDFRetrosynthetic analysis via deep learning to improve pilomatricoma diagnoses.
Comput Biol Med
November 2024
Department of Dermatology, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, 518020, Guangdong, China; Candidate Branch of National Clinical Research Center for Skin Diseases, Shenzhen, 518020, Guangdong, China; Department of Geriatrics, Shenzhen People's Hospital, (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, 518020, Guangdong, China. Electronic address:
Background: Pilomatricoma, a benign childhood skin tumor, presents diagnostic challenges due to its manifestation variations and requires surgical excision upon histological confirmation of its characteristic cellular features. Recent artificial intelligence (AI) advancements in pathology promise enhanced diagnostic accuracy and treatment approaches for this neoplasm.
Methods: We employed a multiscale transfer learning model, initiating the training process at high resolutions and adapting to broader scales.
Article Synopsis
- * Accurate diagnosis relies on histopathological examination, which reveals specific cell characteristics and necessitates clinician awareness for timely intervention.
- * Treatment typically involves complete surgical excision, which effectively reduces the risk of recurrence and leads to favorable outcomes.
Case report: Pilomatrix carcinoma with PDL1 expression and aberrant.
Front Immunol
June 2024
The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, Changsha, China.
Article Synopsis
- A 55-year-old male presented with a mass in the left inguinal area and swelling in the left leg, initially due to unrelieved pain; MRI results indicated significant damage and abnormal tissue signals related to a suspected tumor.
- A biopsy confirmed the mass to be a malignant pilomatrix carcinoma, with evidence of bone metastasis and a significant genetic mutation found through next-generation sequencing.
- The patient underwent chemotherapy with gemcitabine and nedaplatin, but the cancer progressed, suggesting that alternative treatments like PDL1 antibodies and CDK4/6 inhibitors could be more effective.
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