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Amidine-functionalized aggregation-induced emission luminogen and a 3D-printed digital sensor platform for ultrafast and visual detection of heparin.
Anal Chim Acta
February 2025
College of Chemistry, Henan Joint International Research Laboratory of Green Construction of Functional Molecules and Their Bioanalytical Applications, Food Laboratory of Zhongyuan, Zhengzhou University, Zhengzhou, 450001, China.
Background: Heparin is a widely used anticoagulant in clinic. However, improper dosing can increase the risk of thromboembolic events, potentially leading to life-threatening complications. Clinic monitoring of heparin is very important for its use safety.
View Article and Find Full Text PDFBiarsenical-based fluorescent labeling of metallothioneins as a method for ultrasensitive quantification of poly-Cys targets.
Anal Chim Acta
February 2025
Department of Chemical Biology, Faculty of Biotechnology, University of Wroclaw, Joliot-Curie 14a, 50-383, Wrocław, Poland. Electronic address:
Background: Mammalian metallothioneins (MTs) play a crucial role in maintaining Zn(II) and Cu(I) homeostasis, as well as regulating the cellular redox potential. They are involved in cancer resistance to cisplatin-related drugs and the sequestration of toxic metal ions. To investigate their participation in specific physiological and pathological processes, it is imperative to develop an analytical method for measuring changes in protein concentration both in vitro and in vivo.
View Article and Find Full Text PDFCarbon dot embedded hybrid microgel from synthesis to sensing: Experimental and theoretical approach.
Anal Chim Acta
February 2025
Department of Chemistry and Centre of Advanced Studies in Chemistry, Panjab University, Chandigarh, 160014, India; Department of Applied Chemistry, Maulana Abul Kalam Azad University of Technology, Simhat, Haringhata, West Bengal, 741249, India. Electronic address:
Background: The intellectual progress in fabricating artificial probes for selective appraisal of biologically admissible amino acids has displayed exponential growth in recent era.The neoteric era in material science has witnessed the significant application of carbon quantum dots (CQDs). However, the hybrid microgel of CQDs was less explored.
View Article and Find Full Text PDFBifunctional probe propelling multipath strand displacement amplification tandem CRISPR/Cas12a for ultrasensitive and robust assay of DNA methyltransferase activity.
Anal Chim Acta
February 2025
School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan, 450001, China. Electronic address:
Background: DNA methylation catalyzed by various DNA methyltransferases (DNA MTases) is one of the important epigenetic regulations in both eukaryotes and prokaryotes. Therefore, the detection of DNA MTase activity is a vital target and direction in the study of methylation-related diseases.
Results: In this study, an ultrasensitive and robust strategy was developed for DNA MTase activity sensing based on bifunctional probe propelling multipath strand displacement amplification and CRISPR/Cas12a techniques.
A signal amplifying MOF-based probe:on-site and ultrasensitive dual-channel portable detection of Hg in groundwater through a fluorimetrically and RGB-based sensing assay.
Talanta
January 2025
State Key Laboratory of Applied Organic Chemistry, Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, Lanzhou University, Lanzhou, Gansu, 730000, People's Republic of China. Electronic address:
Mercury (II) ions (Hg) are a significant source of heavy metal contamination in groundwater, posing a serious threat to human health and the environment. Therefore, there is an urgent need for the development of a new detection technique with high sensitivity for monitoring Hg in contaminated groundwater. Here, we developed a signal amplifying MOF-based probe (NXS@ZIF-8) for on-site and ultrasensitive dual-channel portable detection of Hg in groundwater.
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