Synthesis and antiviral evaluation of AZT analogues with A spacer arm between glucidic and base moieties. Part II.

Nucleosides Nucleotides Nucleic Acids

Université de Limoges, Laboratoire de Chimie des Substances Naturelles, Faculté des Sciences et Techniques, Limoges, France.

Published: October 2007

AI Article Synopsis

  • - This article discusses the creation of AZT analogues that have a non-cyclic chain connecting the sugar and base parts.
  • - The synthesis process for these compounds was made easier and faster using microwave irradiation.
  • - The new compounds were analyzed using techniques like (1)H NMR and IR spectroscopy, and their effectiveness against HIV-1 was tested.

Article Abstract

This article describes the synthesis of a series of AZT analogues bearing an acyclic chain between the sugar and the base moieties is described. These new compounds were readily obtained using microwave irradiation. The compounds were characterized by (1)H NMR and IR spectroscopy. Antiviral (HIV-1) properties of these compounds were examined.

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http://dx.doi.org/10.1080/15257770701426153DOI Listing

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