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The new gamma interferon (IFN-γ) algorithm for tuberculosis diagnosis in cynomolgus macaques.
PLoS One
December 2024
Office of Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Tuberculosis (TB) is the first infectious disease to be screened-out from specified pathogen-free cynomolgus macaques (Macaca fascicularis; Mf) using in human pharmaceutical testing. Being in either latent or active stage after exposure to the Mycobacterium tuberculosis complex (MTBC), the monkey gamma-interferon release assay (mIGRA) was previously introduced for early TB detection. However, a notable incidence of indeterminate results was observed.
View Article and Find Full Text PDFPerformance of the T-SPOT.TB test in patients with indeterminate QuantiFERON-TB Gold Plus results: proposal for an algorithm for the diagnosis of Latent Tuberculosis Infection.
Infez Med
December 2024
Clinical Microbiology and Virology Laboratory, Papa Giovanni XXIII Hospital, Bergamo, Italy.
Latent Tuberculosis Infection (LTBI) is a state of persistent immune response to complex antigens without clinical, radiological and microbiological signs of active disease. Effective diagnosis and preventive treatment of LTBI are crucial for tuberculosis (TB) control, especially in high-risk groups. Currently, two main tests are used for LTBI diagnosis: the Tuberculin Skin Test (TST) and the Interferon-Gamma Release Assays (IGRA), including the QuantiFERON-TB Gold Plus (QFT-Plus) and the T-SPOT.
View Article and Find Full Text PDFPolymerase Chain Reaction for Detection of in Granulomatous Anterior Uveitis - An Analysis of 51 Eyes.
Ocul Immunol Inflamm
October 2024
Director of Uveitis and Ocular Pathology Department, Sankara Nethralaya, Chennai, India.
Purpose: To evaluate the role of polymerase chain reaction (PCR) in detecting in granulomatous anterior uveitis and comparing the results with those of Mantoux test, QuantiFERON-TB Gold test, and High-Resolution Computed Tomography of Chest (HRCT-chest).
Methods: Data of 51 eyes of 38 patients with clinical features of granulomatous anterior uveitis undergoing anterior chamber fluid aspiration for PCR for MTb targeting IS6110 and MPB64 were studied.
Results: Out of 38 patients, 25 (65.
The impact of an oral glucose load on IFN-γ-release in persons infected with Mycobacterium tuberculosis.
BMC Infect Dis
September 2024
Unit of Infectious Diseases, Department of Medicine, Herlev and Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.
Background And Objective: To diagnose tuberculosis infection (TBI), whole blood is incubated with M.tuberculosis (Mtb)-specific peptides and the release of interferon-γ (IFN-γ) is measured in IFN-γ-release assays (IGRAs). Hyperglycaemia and fluctuations in blood glucose may modulate IFN-γ-release.
View Article and Find Full Text PDFEvaluation of concordance of new QuantiFERON-TB Gold Plus platforms for infection diagnosis in a prospective cohort of household contacts.
Microbiol Spectr
August 2024
Departamento de Enfermedades Infecciosas del Adulto, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
Unlabelled: Interferon-gamma (IFN-γ) release assays play a pivotal role in tuberculosis infection (TBI) diagnosis, with QuantiFERON-TB Gold Plus-an enzyme-linked immunosorbent assay (ELISA)-among the most widely utilized. Newer QuantiFERON-TB platforms with shorter turnaround times were recently released. We aimed to evaluate these platforms' agreement in the diagnosis of TBI.
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