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Colistin methanesulfonate against multidrug-resistant Acinetobacter baumannii in an in vitro pharmacodynamic model. | LitMetric
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Colistin methanesulfonate against multidrug-resistant Acinetobacter baumannii in an in vitro pharmacodynamic model.

Lisa A Kroeger Laurie B Hovde Isaac F Mitropoulos Jeremy Schafer John C Rotschafer

Antimicrob Agents Chemother

Department of Experimental and Clinical Pharmacology, University of Minnesota College of Pharmacy, 9-157 Weaver-Densford Hall, 308 Harvard Street SE, Minneapolis, MN 55455, USA.

Published: September 2007

Using an in vitro pharmacodynamic model, a multidrug-resistant strain of Acinetobacter baumannii was exposed to colistin methanesulfonate alone and in combination with ceftazidime. Pre- and postexposure colistin sulfate MICs were determined. A single daily dose of colistin methanesulfonate combined with continuous-infusion ceftazidime prevented regrowth and postexposure MIC increases.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2043208PMC
http://dx.doi.org/10.1128/AAC.01433-06DOI Listing

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