Members of the genus Yatapoxvirus, which include Tanapox virus (TPV) and Yaba monkey tumor virus, infect primates including humans. Two strains of TPV isolated 50 years apart from patients infected from the equatorial region of Africa have been sequenced. The original isolate from a human case in the Tana River Valley, Kenya, in 1957 (TPV-Kenya) and an isolate from an infected traveler in the Republic of Congo in 2004 (TPV-RoC). Although isolated 50 years apart the genomes were highly conserved. The genomes differed at only 35 of 144,565 nucleotide positions (99.98% identical). We predict that TPV-RoC encodes 155 ORFs, however a single transversion (at nucleotide 10241) in TPV-Kenya resulted in the coding capacity for two predicted ORFs (11.1L and 11.2L) in comparison to a single ORF (11L) in TPV-RoC. The genomes of TPV are A+T rich (73%) and 96% of the sequence encodes predicted ORFs. Comparative genomic analysis identified several features shared with other chordopoxviruses. A conserved sequence within the terminal inverted repeat region that is also present in the other members of the Yatapoxviruses as well as members of the Capripoxviruses, Swinepox virus and an unclassified Deerpox virus suggests the existence of a conserved near-terminal sequence secondary structure. Two previously unidentified gene families were annotated that are represented by ORF TPV28L, which matched homologues in certain other chordopoxviruses, and TPV42.5L, which is highly conserved among currently reported chordopoxvirus sequences.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.virusres.2007.05.001 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Tanapox Virus and Yaba Monkey Tumor Virus K3 Orthologs Inhibit Primate Protein Kinase R in a Species-Specific Fashion.
Viruses
July 2024
Department of Medical Microbiology and Immunology, School of Medicine, University of California, Davis, CA 95616, USA.
Article Synopsis
- Yaba monkey tumor virus (YMTV) and Tanapox virus (TPV), which can infect humans and primates, have unclear reasons for their varying host ranges.
- The study showed that K3 orthologs from YMTV and TPV have different abilities to inhibit the protein PKR across 15 primate species, with TPV being more effective against humans.
- Findings revealed that the region responsible for this difference is located at the C-terminus of the K3 proteins and that specific PKR inhibition patterns can influence how susceptible different primates are to yatapoxvirus infections.
Structural homology-based identification of BEN domain proteins in Poxviruses.
Biochem Biophys Res Commun
June 2024
State Key Laboratory of Common Mechanism Research for Major Diseases, Department of Molecular Biology and Biochemistry, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100005, China. Electronic address:
BEND family transcription factors directly interact with DNA through BEN domains and have been found across metazoan species. Interestingly, certain insect and mammalian viruses have also hijacked Bend genes into their genome. However, the phylogenetic classification and evolution of these viral BEN domains remain unclear.
View Article and Find Full Text PDFPoxiPred: An Artificial-Intelligence-Based Method for the Prediction of Potential Antigens and Epitopes to Accelerate Vaccine Development Efforts against Poxviruses.
Biology (Basel)
February 2024
Department of Microbiology and Immunology, Dalhousie University, Halifax, NS B3H 4H7, Canada.
Article Synopsis
- Poxviruses are a group of large, double-stranded DNA viruses that cause contagious diseases in humans and animals, classified into two subfamilies affecting vertebrates and insects, with 18 genera including those that infect humans like variola virus and monkeypox.
- There is a need for effective vaccines against poxviruses, and new AI-based methods, particularly PoxiPred, have been developed to predict potential antigens and T-cell epitopes for multiple poxvirus strains.
- PoxiPred identified 3,191 antigen proteins across 25 poxviruses and predicted 16,817 T-cell epitopes, predominantly reactive to CD8+ T-cells, streamlining the process of vaccine design using a
Poxvirus infections in dermatology - the neglected, the notable, and the notorious.
J Dtsch Dermatol Ges
January 2024
Department of Dermatology and Venereology, Vivantes Hospital Neukölln, Berlin, Germany.
The family Poxviridae currently comprises 22 genera that infect vertebrates. Of these, members of the Ortho-, Para-, Mollusci- and Yatapoxvirus genera have been associated with human diseases of high clinical relevance in dermatology. Historically, smallpox had been a notorious health threat until it was declared eradicated by the World Health Organization in 1979.
View Article and Find Full Text PDFViral Vectors Expressing Interleukin 2 for Cancer Immunotherapy.
Hum Gene Ther
September 2023
Department of Pharmaceutical and Biomedical Sciences, California Northstate University College of Pharmacy, Elk Grove, California, USA.
Article Synopsis
- * Despite its benefits, IL-2 therapy has downsides, such as a short lifespan in the bloodstream, poor targeting of tumors, and serious side effects at high doses.
- * Oncolytic viruses (OVs) can enhance cancer immunotherapy by safely delivering IL-2 directly to tumors, and combining IL-2 with OVs has shown promising results in preclinical and clinical studies for improving antitumor responses.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!