A novel series of benzimidazoles was identified and optimized, leading to the discovery of potent and selective antagonists of the human melanocortin-4 receptor. In addition, compound 5i was shown to cross the blood-brain barrier after intravenous dosing in rats.
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| http://dx.doi.org/10.1016/j.bmcl.2007.06.010 | DOI Listing |
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