In this paper, the problem of undesirable photonuclear, electronuclear and neutron capture reactions taking place in the treatment room during emission of the typical high-energy therapeutic beams from two different medical accelerators, i.e. Primus Siemens and Varian Clinac-2300, is presented. The radioisotopes (187)W, (56)Mn, (28)Al, (57)Ni, (38)Cl, (57)Co and (19)Au and the neutron activation of (1)H were identified as a consequence of these reactions. Moreover, the increased photon fluence rate behind the door of the accelerator bunker in the operator console room was observed during emission of the 20 MV X-rays from the Varian Clinac-2300 as well as in the case of the 15 MV X-ray beam from the Primus Siemens. No increased radiation was observed during the 6 MV X-ray beam emission. The performed measurements produced evidences on the presence of neutrons in the operator console room during emission of the 15 MV X-ray beam from the Primus Siemens as well as the 20 MV X-rays and the 22 MeV electrons from the Varian Clinac-2300 accelerator.
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http://dx.doi.org/10.1093/rpd/ncm318 | DOI Listing |
Toxics
July 2023
Department of Clinical Oncology (Section of Radiotherapy and Nuclear Medicine), Faculty of Medicine, Medical University of Plovdiv, 4002 Plovdiv, Bulgaria.
Ionizing radiation in radiotherapy can disrupt cellular functions based on radiation type, energy, and dose. However, investigations on the effects of accelerated electrons, particularly on serotonin mediation, are limited. This study aimed to investigate changes in serotonin signal transduction (targeting 5-HT and 5-HT receptors) in gastric smooth muscle (SM) samples isolated from rats irradiated with accelerated electrons (linear accelerator Siemens Primus S/N 3561) and their effects on serotonin-induced reactions.
View Article and Find Full Text PDFJ Med Signals Sens
May 2023
Department of Radiooncology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Background: This study aimed to optimize efficiency in Monte Carlo (MC) simulation using sensitivity analysis of a beam model.
Methods: The BEAMnrc-based model of 6 MV beam of a Siemens Primus linac was developed. For sensitivity analysis, the effect of the electron source, treatment head, and virtual phantom specifications on calculated percent depth dose (PDD) and lateral dose profiles was evaluated.
PLoS One
January 2023
Department of Medical Physics and Biomedical Engineering, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Neutron contamination in radiation therapy is of concern in treatment with high-energy photons (> 10 MV). With the development of new radiotherapy modalities such as spatially fractionated grid radiation therapy (SFGRT) or briefly grid radiotherapy, more studies are required to evaluate the risks associated with neutron contamination. In 15 MV SFGRT, high-Z materials such as lead and cerrobend are used as the block on the tray of linear accelerator (linac) which can probably increase the photoneutron production.
View Article and Find Full Text PDFRadiat Prot Dosimetry
March 2023
Department of Medical Physics, The Advocate Center for Clinical Research, Ayatollah Yasrebi Hospital, Kashan 8715973455, Iran.
To evaluate the beam-matching of two Siemens Primus medical linear accelerators (Linacs), the output factor (Sc,p), wedge factor, quality index (TPR20/10), percentage depth dose (PDD) and beam profiles were compared for 6 and 15 MV photon beams. The output factor, the PDD and the beam profile for electron beam compared for 5, 7, 8, 10 and 12 MeV electron beams. The gamma (γ) analysis of 2 mm/2% and 3 mm/3% was performed.
View Article and Find Full Text PDFHeliyon
September 2022
Department of Medical Physics, University of the Free State, Bloemfontein, 9300, South Africa.
In Intra-Operative Radiation Therapy (IORT) the tumour site is surgically exposed and normal tissue located around the tumour may be avoided. Electron applicators would require large surgical incisions; therefore, the preferred mechanism for beam collimation is the IORT cone system. FLASH radiotherapy (FLASH-RT) involves the treatment of tumours at ultra-high dose rates and the IORT cone system can also be used.
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