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CARDIORESPIRATORY EFFECTS OF VATINOXAN IN BLESBOK () IMMOBILIZED WITH THIAFENTANIL-MEDETOMIDINE.
J Zoo Wildl Med
September 2024
Wildlife Pharmaceuticals South Africa (Pty) Ltd, White River 1240, South Africa.
Combinations of a low dose of opioid, such as thiafentanil, and a high dose of medetomidine, are increasingly being used for immobilization of African ungulates. Both drugs can have undesirable cardiorespiratory effects. In this study we assessed whether vatinoxan, a peripherally acting alpha-adrenergic receptor antagonist, can be used to alleviate some of these effects without affecting the immobilization quality.
View Article and Find Full Text PDFRisk factors and operative risk of large vessel occlusion and stroke during cardiac surgery.
J Stroke Cerebrovasc Dis
November 2024
Department of Neurology, University of Pittsburgh Medical Center, United States; Department of Neurological Surgery, University of Pittsburgh Medical Center, United States.
Objective: Perioperative Large Vessel Occlusions (LVOs) occurring during and following surgery are of immense clinical importance. As such, we aim to present risk factors and test if the Society of Thoracic Surgery (STS) mortality and stroke risk scores can be used to assess operative risk.
Methods: Using data containing 7 index cardiac operations at a single tertiary referral center from 2010 to 2022, logistic and multivariate regression analysis was performed to identify factors that correlate to higher operative LVO and stroke rate.
Sedaconda ACD-S for Sedation with Volatile Anaesthetics in Intensive Care: A NICE Medical Technologies Guidance.
Appl Health Econ Health Policy
November 2024
CEDAR, Cardiff and Vale University Health Board, Cardiff, UK.
Intensive care unit (ICU) patients receive highly complex care and often require sedation as part of their management. ICU sedation has traditionally been delivered using intravenous (IV) agents due to the impractical use of anaesthetic machines in this setting, which are used to deliver volatile sedation. Sedaconda anaesthetic conserving device (ACD)-S (previously known as AnaConDa-S) is a device which allows for the delivery of volatile sedation via the majority of mechanical ventilators by being inserted in the breathing circuit where the heat and moisture exchanger is normally placed.
View Article and Find Full Text PDFImpact of procedural handling on the physiological effects of alfaxalone anaesthesia in the ball python (Python regius).
Comp Biochem Physiol A Mol Integr Physiol
November 2024
Section for Zoophysiology, Department of Biology, Aarhus University, Aarhus, Denmark; Department of Animal and Veterinary Science, Aarhus University, Tjele, Denmark. Electronic address:
To describe the cardiovascular changes following intramuscular (handled) and intravascular (undisturbed, via intraarterial catheter) alfaxalone administration, we studied 20 healthy ball pythons (Python regius) in a randomised, prospective study. The pythons were instrumented with occlusive arterial catheters to facilitate undisturbed, continuous monitoring of heart rate and blood pressure. Six pythons were administered intramuscular (IM) saline, followed by 20 mg/kg IM alfaxalone, and were manually restrained for both injections.
View Article and Find Full Text PDFEndovascular therapy of isolated posterior cerebral artery occlusion stroke with and without general anesthesia.
J Neurointerv Surg
August 2024
Department of Neurology, Heidelberg University Hospital, Heidelberg, Germany.
Article Synopsis
- The study investigates the effectiveness of two anesthesia methods—general anesthesia (GA) and conscious sedation (non-GA)—for patients undergoing endovascular treatment for isolated posterior cerebral artery (PCA) occlusion stroke.
- Researchers analyzed data from the PLATO study focusing on patient outcomes such as the modified Rankin Scale scores after 90 days, as well as successful reperfusion rates and safety measures like intracranial hemorrhage.
- Results show that while both anesthesia methods had similar functional outcomes and safety profiles, GA was associated with significantly higher rates of successful reperfusion during treatment.
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