Semantic memory impairments have been reported extensively in people with schizophrenia. Inefficient search and retrieval strategies, due to an executive dysfunction, rather than a primary loss of semantic knowledge are a primary candidate for such impairments. In order to test this hypothesis we compared the performance of 20 patients meeting DSM-IV-TR criteria for schizophrenia with that of 20 healthy controls and 10 patients with acquired brain injury (ABI) with a dysexecutive syndrome. Seventy percent of the people with schizophrenia and 100% of the ABI patients in this study met criteria for executive impairment. However, the two groups performed significantly differently on a range of semantic memory tests. Whereas 45% of the patients with schizophrenia met criteria for distorted semantic category boundaries (n.b. overinclusion), this was true for only 10% of the ABI patients. In addition, no correlation was found between severity of executive dysfunction and tendency to overinclude in the schizophrenia group. This pattern of neuropsychological findings suggests that overinclusion, or disorganized semantic categorization procedures, in schizophrenia does not result from a classical executive dysfunction. Alternative explanations are discussed.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1016/j.schres.2007.04.012 | DOI Listing |
Brain Behav
January 2025
School of Physical Education, Shanghai University of Sport, Shanghai, China.
Objective: To explore the mediating pathway of cognitive flexibility in the relationship between physical activity and depressive symptoms among university students.
Methods: A cross-sectional design was used to survey 2537 university students using the Physical Activity Rating Scale-3, Patients' Health Questionnaire, and Cognitive Flexibility Inventory. Data analysis was conducted using independent samples t-test, chi-square test, correlation analysis, one-way ANOVA, and mediation analysis.
J Biophotonics
January 2025
School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Motor dysfunction of the upper limbs following a stroke predominantly arises from abnormal motor patterning caused by the disrupted balance of inter-cortical communication within motor-associated cortical regions. Temporal analysis offers a more precise reflection of the cortical functional state in affected patients. This study employed fNIRS to capture hemodynamic responses among 20 stroke patients and 19 healthy controls in both resting and Baduanjin task state.
View Article and Find Full Text PDFAppl Neuropsychol Adult
January 2025
Department of Psychology, Chung Shan Medical University, Taichung, Taiwan.
In this cross-sectional analysis, we explored how fluctuations in glycemic levels impact executive functions and psychosocial outcomes in patients with type 2 diabetes mellitus (T2DM). The goal was to understand the relationship between glycemic control and both neuropsychological and psychosocial health. We stratified participants into well-controlled and poorly controlled groups based on glycated hemoglobin (HbA1c) levels and variability, including a healthy control group for comparison.
View Article and Find Full Text PDFNeurochem Res
January 2025
Department of Anesthesiology, Shengjing Hospital of China Medical University, Shenyang, China.
Perioperative neurocognitive disorders (PND) is a common complication affecting the central nervous system, commonly induced by anesthesia and surgical procedures. PND has garnered considerable attention in recent years, not only due to its high morbidity but also its negative impact on patient prognosis, such as increased rates of dementia and mortality. Sevoflurane, a common volatile anesthetic in clinical practice, is increasingly linked to being a potential risk factor for PND with prolonged inhalation, yet effective prevention and treatment methods remain elusive.
View Article and Find Full Text PDFBiol Psychiatry Glob Open Sci
November 2024
Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Background: Evidence for widespread comorbidity of executive dysfunctions with psychiatric disorders suggests common mechanisms underlying their pathophysiology. However, the shared genetic architectures between psychiatric disorders and executive function (EF) remain poorly understood.
Methods: Leveraging large genome-wide association study datasets of European ancestry on bipolar disorder ( = 353,899), major depressive disorder ( = 674,452), and schizophrenia ( = 130,644) from the Psychiatric Genomics Consortium and iPSYCH and a common factor of EF ( = 427,037) from UK Biobank, we systematically investigated the shared genomic architectures between psychiatric disorders and EF with a set of statistical genetic, functional genomic, and gene-level analyses.
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!