The authors analyze mortality rates during 338,000 anesthetic procedures. Mortality was 0.02%. Epidural, spinal, and plexus anesthesias were 15% of the total number of anesthetic procedures. In this group, mortality was twice less [0.01% (6 patients)] than that under general anesthesia. Under regional anesthesia, all deaths were associated with the induction of epidural anesthesia. A human factor is of profound importance for fatal cases under regional anesthesia. Regional anesthetic techniques are safer than general anesthetic ones.
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Alzheimers Dement
December 2024
Mashhad University of Medical Sciences, Mashhad, Razavi Khorasan, Iran (Islamic Republic of).
Background: Microbiota of the distal part of the intestine produces Urolithin A (Uro A) as a derivative of ellagitannins hydrolysis. Recently, the mitophagy, anti-inflammatory, and antioxidant properties of Uro A have focused more attention on its probable beneficial effects on neurodegenerative states. The purpose of this research was to study the impact of Uro A on the histopathology of the cerebellum in a rat model of streptozotocin-induced Alzheimer's disease.
View Article and Find Full Text PDFClin J Pain
January 2025
Department of Anesthesiology, Critical Care, and Pain Medicine, Boston Children's Hospital, Boston, MA, USA.
Objectives: Chronic pain (CP) significantly impacts emotional and physical well-being and overall quality of life across diverse populations in the United States (U.S.).
View Article and Find Full Text PDFClin J Pain
January 2025
Biostatistics Group, Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan.
Objectives: Postoperative pain, nausea and vomiting adversely affect postoperative rehabilitation after total knee arthroplasty (TKA). We aimed to identify factors associated with postoperative pain trajectory and postoperative nausea and vomiting (PONV) and evaluated the effects of different analgesic modalities.
Methods: We retrospectively reviewed patients undergoing unilateral primary TKA from 2017 to 2022.
Clin J Pain
January 2025
Department of Anesthesiology Critical Care Medicine, The Saban Research Institute at Children's Hospital Los Angeles, The Biobehavioral Pain Lab.
Objectives: Chronic pain is a leading cause of morbidity in children and adolescents globally but can be managed with a combination of traditional Western medicine and integrative medicine (IM) practices. This combination has improved various critical health outcomes, such as quality-of-life, sleep, pain, anxiety, and healthcare utilization. These IM practices include acupuncture, yoga, biofeedback, massage, mindfulness, or any combination of these modalities.
View Article and Find Full Text PDFCurr Med Chem
January 2025
Department of Pediatrics, The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, China.
Background: Hyperuricemia (HUA) is a condition characterized by excessive uric acid production and/or inadequate uric acid excretion due to abnormal purine metabolism in the human body. Uric acid deposits resulting from HUA can lead to complications such as renal damage. Currently, drugs used to treat HUA lack specificity and often come with specific toxic side effects.
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