Objective: To determine the effects of three anesthetic regimens on serum calcium and parathyroid hormone (PTH) in mice.
Study Design: Prospective experimental study.
Animals: Twenty-seven, 12-week-old, FVB mice.
Methods: Mice were anesthetized with either isoflurane, a combination of ketamine plus xylazine (100 and 10 mg kg(-1), respectively) or ketamine alone (100 mg kg(-1)). Blood was collected before and after the induction of anesthesia. Serum calcium and PTH concentrations were measured and compared.
Results: Isoflurane or ketamine did not significantly alter either serum calcium or serum PTH concentrations. A combination of ketamine plus xylazine significantly increased serum PTH, but not serum calcium concentrations.
Conclusions: A combination of ketamine and xylazine should be avoided prior to collection of blood for measurement of serum PTH concentrations. Isoflurane is suitable for this purpose.
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http://dx.doi.org/10.1111/j.1467-2995.2006.00341.x | DOI Listing |
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