Effects of anesthetic agents on serum parathyroid hormone and calcium concentrations in mice.

Vet Anaesth Analg

Department of Oral Health and Diagnostic Sciences, University of Connecticut School of Dental Medicine, Farmington, CT 06030-3101, USA.

Published: November 2007

Objective: To determine the effects of three anesthetic regimens on serum calcium and parathyroid hormone (PTH) in mice.

Study Design: Prospective experimental study.

Animals: Twenty-seven, 12-week-old, FVB mice.

Methods: Mice were anesthetized with either isoflurane, a combination of ketamine plus xylazine (100 and 10 mg kg(-1), respectively) or ketamine alone (100 mg kg(-1)). Blood was collected before and after the induction of anesthesia. Serum calcium and PTH concentrations were measured and compared.

Results: Isoflurane or ketamine did not significantly alter either serum calcium or serum PTH concentrations. A combination of ketamine plus xylazine significantly increased serum PTH, but not serum calcium concentrations.

Conclusions: A combination of ketamine and xylazine should be avoided prior to collection of blood for measurement of serum PTH concentrations. Isoflurane is suitable for this purpose.

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1467-2995.2006.00341.xDOI Listing

Publication Analysis

Top Keywords

serum calcium
16
combination ketamine
12
ketamine xylazine
12
pth concentrations
12
serum pth
12
serum
8
parathyroid hormone
8
100 kg-1
8
calcium
5
pth
5

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!