Immunoassay interference caused by reagents (additives, excipients) incorporated in the blood sampling systems is undetectable by the conventional methods for intralaboratory quality control, by using reference substances. A large number of manufacturers and a great physicochemical variety of additives in the current vacuum and non-vacuum systems require that additional measures be made to monitor systemic errors in immunochemical studies. The review considers the mechanisms of this type of interference and the problems of its monitoring and prevention.
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