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Distinct Network Morphologies from In Situ Polymerization of Microtubules in Giant Polymer-Lipid Hybrid Vesicles.
Adv Biol (Weinh)
March 2025
Department of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan, 48109, USA.
Creating artificial cells with a dynamic cytoskeleton, akin to those in living cells, is a major goal in bottom-up synthetic biology. In this study, we demonstrate the in situ polymerization of microtubules encapsulated in giant polymer-lipid hybrid vesicles (GHVs) composed of 1,2-dioleoyl-sn-glycero-3-phosphocholine and an amphiphilic block copolymer. The block copolymer is comprised of poly(cholesteryl methacrylate-co-butyl methacrylate) as the hydrophobic block and either poly(6-O-methacryloyl-D-galactopyranose) or poly(carboxyethyl acrylate) as the hydrophilic extension.
View Article and Find Full Text PDFJanus Polymeric Giant Vesicles on Demand: A Predictive Phase Separation Approach for Efficient Formation.
J Am Chem Soc
March 2025
Univ. Bordeaux, CNRS, Bordeaux INP LCPO, UMR 5629, Pessac F-33600, France.
Janus particles, with their intrinsic asymmetry, are attracting major interest in various applications, including emulsion stabilization, micro/nanomotors, imaging, and drug delivery. In this context, Janus polymersomes are particularly attractive for synthetic cell development and drug delivery systems. While they can be achieved by inducing a phase separation within their membrane, their fabrication method remains largely empirical.
View Article and Find Full Text PDFSynthesis Method and High Salt Concentration Can Affect Electrodeformation of GUVs under Strong Pulsed DC Fields.
ACS Omega
February 2025
Department of Chemical Engineering, Indian Institute Technology of Bombay, Mumbai 400076, India.
The study focuses on two important issues in the electrodeformation of giant unilamellar vesicles (GUVs) as biomimic objects, with regard to their electroporation. The results are presented with respect to the ratio of the conductivities of the inner and outer fluids of the GUV, (β = Λ/Λ), and the concentration of salt in the enclosed medium ( ). In this work, low and high salt concentration regimes are referred to as ≤ 0.
View Article and Find Full Text PDFIncorporation of Triacylglycerol and Cholesteryl Ester Droplets in Phase-Separated Giant Unilamellar Vesicles.
Langmuir
March 2025
Research Center for Macromolecules and Biomaterials, National Institute for Materials Science, 1-1 Namiki, Tsukuba, Ibaraki 305-0044, Japan.
Cytoplasmic lipid droplets form from the endoplasmic reticulum (ER). Because the ER membrane can undergo phase separation, the interaction of lipid droplets with phase-separated bilayers is of significant interest. In this study, we used fluorescence microscopy to investigate the incorporation of droplets composed of triolein, trilinolein, trimyristolein, trieicosenoin, and cholesteryl arachidonate in the bilayers of giant unilamellar vesicles (GUVs) consisting of a mixture of 1,2-dioleoyl--glycero-3-phosphocholine (DOPC), 1,2-dipalmitoyl--glycero-3-phosphocholine (DPPC), and cholesterol.
View Article and Find Full Text PDFDe-Novo Design of Actively Spinning and Gyrating Spherical Micro-Vesicles.
Adv Mater
February 2025
Department of Chemical Sciences, Indian Institute of Science Education and Research Mohali, Punjab, 140306, India.
Self-propelled lipid-based artificial cells that can achieve controlled rotation and directed translation present significant potential for biomedical applications, yet their engineering poses considerable challenges. Lipid vesicles synthesized via solution-based methods naturally adopt isotropic spherical shapes. Active motion of these spherical objects requires symmetry breaking and rigidity.
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