Census data suggest that persons over 84 years of age represent the fastest growing segment of populations in most western nations. As advancing age remains the single strongest risk factor for dementia, prevalence rates are expected to increase substantially in coming years. This awareness underscores the need to more fully understand the clinical presentation of Alzheimer disease and other neurodegenerative disorders. The present study examines responses to the 28-item Dementia Behaviour Disturbance Scale (DBD; Baumgarten, Becker, & Gauthier, 1990) among a national sample of persons with dementia (PWD) in Canada. A 3-factor solution appears to best reflect DBD responses for both institutionalized and community-dwelling PWD. This finding is notable given that the former was significantly more impaired and presented with significantly greater levels of behavioural disturbance. Support for the factorial validity of these constructs is provided relative to caregiver burden and depressive symptomatology. Of note, only 14 of 28 DBD items were retained in our analyses; on this basis, we propose the use of an abridged version of the scale. These findings can be generalized with greater confidence given the random and representative nature of the PWD and caregiver samples.
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http://dx.doi.org/10.1080/13607860600963422 | DOI Listing |
Acta Pharmacol Sin
January 2025
Laboratory for Neurophysiology, Department of Cell and Chemical Biology, Leiden University, Medical Centre, Leiden, 2333, ZC, The Netherlands.
Daylength (i.e., photoperiod) provides essential information for seasonal adaptations of organisms.
View Article and Find Full Text PDFClin Exp Med
January 2025
Department of Hepatobiliary Surgery, the First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Donafenib is an improved version of sorafenib in which deuterium is substituted into the drug's chemical structure, enhancing its stability and antitumor activity. Donafenib exhibits enhanced antitumor activity and better tolerance than sorafenib in preclinical and clinical studies. However, the specific mechanism of its effect on hepatocellular carcinoma has not been reported.
View Article and Find Full Text PDFEcotoxicol Environ Saf
January 2025
Key Laboratory of Zoological Systematics and Application, College of Life Sciences, Hebei University, Baoding 071002, China. Electronic address:
The increasing utilization of antimony (Sb) in manufacturing industries has led to the emergence of Sb contamination in the environment as a significant public health concern. To elucidate the toxicity of Sb and its mechanism of action, this study aimed to investigate the adverse effects of Sb on a cosmopolitan insect, housefly (Musca domestica), under a whole life cycle (from embryonic to adult stage) exposure through the examination of a suite of parameters, including biological, physiological, behavioral, and molecular endpoints. A range of Sb concentrations, including moderate contamination (0.
View Article and Find Full Text PDFInt Immunopharmacol
January 2025
Anhui University of Chinese Medicine, Hefei, Anhui 230012, China.
Objective: In China, Chinese herbal medicines (CHMs) have been widely used in the treatment of psoriatic arthritis (PsA), showing great therapeutic effects in clinical practice. However, due to the great heterogeneity of PsA and the diversity of CHM combination patterns, there is little high-level evidence-based medical research on the treatment of PsA with CHMs. This study aims to explore the beneficial effects of CHMs on the immune inflammation in PsA and its specific mechanism.
View Article and Find Full Text PDFPLoS One
January 2025
Department of Disease Control and Environmental Health, School of Public Health, Makerere University, Kampala, Uganda.
Background: Psychoactive substance use in adults and second-hand smoke (SHS) exposure among children are leading contributors to sleeping problems. Despite this, there is limited data on how these exposures influence sleep patterns in informal settings. Our study assessed the associations between substance use, SHS exposure and sleep disturbances among adults and children in an urban informal settlement in Uganda.
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