Purpose: Stroke is the leading cause of disability in the United States. At present, there is a paucity of experimental evidence available to indicate what physical therapy techniques are effective for improving mobility in an individual with chronic stroke. The purpose of this study was to determine the feasibility and effect size of an intensive mobility training program for people with chronic stroke.
Method: A convenience sample of eight individuals with chronic stroke received an intensive mobility intervention for 3 hours per day for 10 consecutive weekdays. Treatment outcomes were assessed using standardized outcomes of gait, balance, and mobility including the GAITRite to collect spatial and temporal parameters of gait, the Falls Efficacy Scale, Berg Balance Scale, Dynamic Gait Index, and Timed Up and Go. Data were collected at four different time points: baseline, pre-test, post-test, and 3 months after intervention.
Results: The overall effect size of the intervention was 0.72, with changes in balance having much greater effects than changes in gait or mobility. The group demonstrated an average improvement from pre- to post-tests of 12 points on the Berg Balance Scale where a change of 6 is considered a minimal detectable change.
Conclusions: This intense mobility training was a feasible intervention for this sample and demonstrated large effect sizes for balance outcome measures. Future studies incorporating more participants, a standard control, and more emphasis on gait would provide insight into the effectiveness and clinical relevance of this intervention.
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http://dx.doi.org/10.1097/NPT.0b013e3180674a3c | DOI Listing |
Brain Topogr
January 2025
Department of Neurology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT, 06520, USA.
Aberrant large-scale resting-state functional connectivity (rsFC) has been frequently documented in ischemic stroke. However, it remains unclear about the altered patterns of within- and across-network connectivity. The purpose of this meta-analysis was to identify the altered rsFC in patients with ischemic stroke relative to healthy controls, as well as to reveal longitudinal changes of network dysfunctions across acute, subacute, and chronic phases.
View Article and Find Full Text PDFChin Med
January 2025
Yunnan Key Laboratory of Integrated Traditional Chinese and Western Medicine for Chronic Disease in Prevention and Treatment, Key Laboratory of Acupuncture and Massage for Treatment of Encephalopathy, College of Acupuncture, Tuina and Rehabilitation, Yunnan University of Traditional Chinese Medicine, Kunming, China.
Objective: Electroacupuncture has been shown to play a neuroprotective role following ischemic stroke, but the underlying mechanism remains poorly understood. Ferroptosis has been shown to play a key role in the injury process. In the present study, we wanted to explore whether electroacupuncture could inhibit ferroptosis by promoting nuclear factor erythroid-2-related factor 2 (Nrf2) nuclear translocation.
View Article and Find Full Text PDFEur J Pharmacol
January 2025
State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Department of Pharmacology, College of Pharmacy, and Department of Cardiology, the Second Affiliated Hospital, Harbin Medical University, Harbin 150081, China; State Key Labratoray-Province Key Laboratories of Biomedicine-Pharmaceutics of China, and Key Laboratory of Cardiovascular Research, Ministry of Education, College of Pharmacy, Harbin 150081, China; Research Unit of Noninfectious Chronic Diseases in Frigid Zone (2019RU070), Chinese Academy of Medical Sciences, Harbin 150081, China. Electronic address:
Hyperlipidemia is a major risk factor for hypertension, coronary heart disease, diabetes and stroke, triggering an intensified research efforts into its prevention and treatment. Tetrahydroberberrubine (THBru) is a derivative of berberine (BBR) that has been shown to have higher bioavailability and lower toxicity compared to its parent compound. However, its impact on hyperlipidemia has not been fully explored.
View Article and Find Full Text PDFCurr Vasc Pharmacol
January 2025
Department of Cardiology, Ippokrateio University Hospital, Athens, Greece.
Introduction/objective: Emotional, mental, or psychological distress, defined as increased symptoms of depression, anxiety, and/or stress, is common in patients with chronic diseases, such as cardiovascular (CV) disease (CVD).
Methods: Literature was reviewed regarding data from studies and meta-analyses examining the impact of emotional stress on the occurrence and outcome of several CVDs (coronary disease, heart failure, hypertension, arrhythmias, stroke). These influences' pathophysiology and clinical spectrum are detailed, tabulated, and pictorially illustrated.
Int J Health Plann Manage
January 2025
Institute of General Practice and Interprofessional Care, University Hospital Tuebingen, Tuebingen, Germany.
Health care systems are confronted with an increasing burden of (multi-)morbidity and a shortfall of healthcare providers. Coordination and continuity of care in chronic and multi-morbid patient is especially important. As qualitative patient experience data within care processes is scarce, we aim to increase the understanding of chronically ill patient's perspectives by assessing patient experiences in different health systems while treated in primary care.
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