An elevation in cytosolic Ca2+ is a universal signaling mechanism that controls a vast array of physiological processes. K+ -dependent Na+/Ca2+ exchangers are a newly identified family of Ca2+ efflux transporters that play important and diverse roles in cellular Ca2+ homeostasis.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1152/physiol.00001.2007 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Chronotropic effects of milrinone in a guinea pig ex vivo model: a pilot study to screen for new mechanisms of action.
J Cardiovasc Pharmacol
January 2025
Division of Clinical Physiology, Department of Cardiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
Positive inotropic responses upon administration of milrinone, an inhibitor of the phosphodiesterase enzyme (PDE), involve a well-pronounced positive chronotropic effect. Here we tested whether milrinone evokes this chronotropic response solely by PDE inhibition or by a concerted action that involve additional pharmacological targets. Milrinone stimulated increases in heart rate were studied in right atrial preparations of guinea pig in the presence or absence of inhibitors of putative ancillary molecular pathways or ion channels: i.
View Article and Find Full Text PDFThe role of cationic bridges in enhancing sulfamethoxazole adsorption onto montmorillonite.
Environ Geochem Health
January 2025
Yunnan Provincial Key Laboratory of Soil Carbon Sequestration and Pollution Control, Faculty of Environmental Science and Engineering, Kunming University of Science and Technology, Kunming, 650500, Yunnan, China.
The coexistence and interaction of free metal cations in the environment can significantly affect the migration of organic pollutants, leading to varied effects depending on environmental conditions. However, the mechanisms affecting the adsorption of organic pollutants in the presence of metal ions remain poorly understood due to limited molecular-level studies. This study investigated the adsorption behavior of sulfamethoxazole (SMX) on montmorillonite (MT) at different pH values (1.
View Article and Find Full Text PDFEnhanced Prediction of CO-Brine Interfacial Tension at Varying Temperature Using a Multibranch-Structure-Based Neural Network Approach.
Langmuir
January 2025
Key Laboratory of Ocean Energy Utilization and Energy Conservation of Ministry of Education, School of Energy and Power Engineering, Dalian University of Technology, Dalian 116023, P. R. China.
Interfacial tension () between CO and brine depends on chemical components in multiphase systems, intricately evolving with a change in temperature. In this study, we developed a convolutional neural network with a multibranch structure (MBCNN), which, in combination with a compiled data set containing measurement data of 1716 samples from 13 available literature sources at wide temperature and pressure ranges (273.15-473.
View Article and Find Full Text PDFCa/Calmodulin-Dependent Protein Kinase II (CaMKII) Regulates Basal Cardiac Pacemaker Function: Pros and Cons.
Cells
December 2024
Laboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, National Institute of Health, Baltimore, MD 21224, USA.
The spontaneous firing of the sinoatrial (SA) node, the physiological pacemaker of the heart, is generated within sinoatrial nodal cells (SANCs) and is regulated by a "coupled-clock" pacemaker system, which integrates a "membrane clock", the ensemble of ion channel currents, and an intracellular "Ca clock", sarcoplasmic reticulum-generated local submembrane Ca releases via ryanodine receptors. The interactions within a "coupled-clock" system are modulated by phosphorylation of surface membrane and sarcoplasmic reticulum proteins. Though the essential role of a high basal cAMP level and PKA-dependent phosphorylation for basal spontaneous SANC firing is well recognized, the role of basal CaMKII-dependent phosphorylation remains uncertain.
View Article and Find Full Text PDFThe inhibition of SLC8A1 promotes Ca-dependent cell death in Gastric Cancer.
Biomed Pharmacother
January 2025
Department of Biology, University of Naples Federico II, Naples, Italy; Biogem, Istituto di Biologia e Genetica Molecolare, Ariano Irpino, AV, Italy.
Intracellular Ca homeostasis dysregulation, through the modulation of calcium permeable ion channels and transporters, is gaining attention in cancer research as an apoptosis evasion mechanism. Recently, we highlighted a prognostic role for several calcium permeable channels. Among them, here, we focused on the plasma membrane bidirectional Na/Ca exchanger SLC8A1.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!