Objective: To investigate the distribution characters and linkage disequilibrium of apolipoprotein M gene (APOM) polymorphisms in Han population of North China.
Methods: The single nucleotide polymorphisms (SNPs) in six exons and five introns of APOM gene of 330 normal subjects in Han population of North China were detected by PCR-restriction fragment length polymorphism and DNA sequencing analysis.
Results: Three SNPs in Han Chinese were found, including rs805264 of intron 1, rs707922 and rs707921 of intron 5 of APOM gene. The frequency distribution of these SNPs was different among different races and territory. In addition, linkage disequilibrium among the SNPs of rs805264, rs707922 and rs707921 of APOM gene was found and A-T-A and G-G-C were predominant haplotypes.
Conclusion: There is apparent linkage disequilibrium among SNPs of APOM gene in Han population of North China.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
APOM Modulates the Glycolysis Process in Liver Cancer Cells by Controlling the Expression and Activity of HK2 via the Notch Pathway.
Biochem Genet
January 2025
Anhui Province Key Laboratory of Basic Research and Transformation of Age-Related Diseases, Wannan Medical College, Wuhu, 241002, Anhui, P. R. China.
The metabolic pathway of aerobic glycolysis in tumor cells has garnered significant attention in tumor research because of its high activation in cancer cells. Previous research conducted by our team has demonstrated that Apolipoprotein M (APOM) exhibits potential as a factor against liver cancer. However, further investigations are needed to elucidate the precise approach and mechanism that are involved in this process.
View Article and Find Full Text PDFIdentifying prioritization of therapeutic targets for ankylosing spondylitis: a multi-omics Mendelian randomization study.
J Transl Med
December 2024
The First Affiliated Hospital of Chongqing Medical University, Chongqing Branch (Municipality Division) of National Clinical Research Center for Ocular Diseases, Youyi Road 1, Chongqing, 400016, People's Republic of China.
Background: To investigate the associations of methylation, expression, and protein quantitative trait loci (mQTL, eQTL, and pQTL) with ankylosing spondylitis (AS) and find out genetically supported drug targets for AS.
Methods: The summary-data-based Mendelian randomization (SMR) and Bayesian co-localization analysis were used to assess the potential causality between AS and relevant genes. The GWAS data obtained from the International Genetics of Ankylosing Spondylitis Consortium (IGAS) were set as the discovery stage, and the FinnGen and UK Biobank databases were used to replicate the analysis as an external validation.
Insights into Medication-Induced Osteonecrosis of the Jaw Through the Application of Salivary Proteomics and Bioinformatics.
Int J Mol Sci
November 2024
Faculty of Medicine, University of P. J. Šafárik, 041 90 Košice, Slovakia.
Long-term treatment with bisphosphonates is accompanied by an increased risk of medication-related osteonecrosis of the jaw (MRONJ). Currently, no clinically useful biomarkers for the predictive diagnosis of MRONJ are available. To investigate the potential key proteins involved in the pathogenesis of MRONJ, a proteomic LC-MS/MS analysis of saliva was performed.
View Article and Find Full Text PDFEffect of phospholipid transfer protein on plasma sphingosine-1-phosphate.
J Biol Chem
November 2024
Department of Cell Biology, SUNY Downstate Health Sciences University, Brooklyn, New York, USA; Molecular and Cellular Cardiology Program, VA New York Harbor Healthcare System, Brooklyn, New York, USA. Electronic address:
Article Synopsis
- Plasma phospholipid transfer protein (PLTP) is linked to cardiovascular diseases and is thought to influence levels of sphingosine-1-phosphate (S1P), a lipid mediator found in high-density lipoprotein (HDL).
- Research using knockout (KO) mice showed that both PLTP deficiency and double deficiency (with apoM) lead to a significant reduction in HDL and plasma S1P levels, with PLTP deficiency also lowering apoM levels.
- The study concluded that PLTP does not act as a direct carrier for S1P, but its depletion or overexpression affects S1P levels dramatically due to changes in HDL.
The adipocyte apolipoprotein M is negatively associated with inflammation.
J Lipid Res
October 2024
Institute of Metabolic and Cardiovascular Diseases (I2MC), Team MetaDiab, Institut National de la Santé et de la Recherche Médicale (Inserm), Université Toulouse III, Paul Sabatier (UPS), UMR1297, Toulouse, France. Electronic address:
Obesity is associated with the development of local adipose tissue (AT) and systemic inflammation. Most adipokines are upregulated with obesity and have pro-inflammatory properties. Few are downregulated and possess beneficial anti-inflammatory effects.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!