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Effectiveness of low-dose amitriptyline and mirtazapine in patients with insomnia disorder with sleep maintenance problems: a randomised, double-blind, placebo-controlled trial in general practice (DREAMING).
Br J Gen Pract
January 2025
Amsterdam UMC Locatie Meibergdreef, Vrije Universiteit, Department of General Practice, Amsterdam, Netherlands.
Background: Low-dose amitriptyline and mirtazapine are widely prescribed off-label for insomnia disorder. However, evidence from placebo-controlled studies is lacking.
Aim: To assess the effectiveness of low-dose mirtazapine and amitriptyline in patients with insomnia disorder.
Growth Factor Stimulation Regimes to Support the Development and Fusion of Cartilage Microtissues.
Tissue Eng Part C Methods
January 2025
Trinity Centre for Biomedical Engineering, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
Scaffold-free tissue engineering strategies using cellular aggregates, microtissues, or organoids as "biological building blocks" could potentially be used for the engineering of scaled-up articular cartilage or endochondral bone-forming grafts. Such approaches require large numbers of cells; however, little is known about how different chondrogenic growth factor stimulation regimes during cellular expansion and differentiation influence the capacity of cellular aggregates or microtissues to fuse and generate hyaline cartilage. In this study, human bone marrow mesenchymal stem/stromal cells (MSCs) were additionally stimulated with bone morphogenetic protein 2 (BMP-2) and/or transforming growth factor (TGF)-β1 during both monolayer expansion and subsequent chondrogenic differentiation in a microtissue format.
View Article and Find Full Text PDFObservation of broadband super-absorption of electromagnetic waves through space-time symmetry breaking.
Sci Adv
January 2025
School of Electrical and Computer Engineering, Cornell University, Ithaca, NY 14853, USA.
Using time as an additional design parameter in electromagnetism, photonics, and wave physics is attracting considerable research interest, motivated by the possibility to explore physical phenomena and engineering opportunities beyond the limits of time-invariant systems. Here, we report the experimental demonstration of enhanced broadband absorption of electromagnetic waves in a continuously modulated time-varying system, exceeding one of the key theoretical limits of linear time-invariant absorbers. This is achieved by harnessing the frequency-wave vector transitions and enhanced interference effects enabled by breaking both continuous space- and time-translation symmetries in a periodically time-modulated absorbing structure operating at radio frequencies.
View Article and Find Full Text PDFShort-term impact of low air pressure on plants' functional traits.
PLoS One
January 2025
Department of Biotechnology, University of Verona, Verona, Italy.
Lower atmospheric pressure affects biologically relevant physical parameters such as gas partial pressure and concentration, leading to increased water vapor diffusivity and greater soil water content loss through evapotranspiration. This might impact plant photosynthetic activity, resource allocation, water relations, and growth. However, the direct impact of low air pressure on plant physiology is largely unknown.
View Article and Find Full Text PDFUniversality in diffusion-controlled nucleation and growth.
J Chem Phys
January 2025
Center for Functional Nanomaterials, Brookhaven National Laboratory, Upton, New York 11973, USA.
Nucleation and growth are studied in a system that undergoes diffusion-controlled condensation under gradual changes in parameters, such as cooling. It is demonstrated that when the Gibbs-Thompson effect becomes negligible, the system falls into a universal regime. i.
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