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Ancient divergence time estimates in support the existence of Pleistocene barriers on the exposed Sunda Shelf.
PeerJ
October 2017
Department of Biology, Villanova University, Villanova, PA, United States of America.
Episodic sea level changes that repeatedly exposed and inundated the Sunda Shelf characterize the Pleistocene. Available evidence points to a more xeric central Sunda Shelf during periods of low sea levels, and despite the broad land connections that persisted during this time, some organisms are assumed to have faced barriers to dispersal between land-masses on the Sunda Shelf. is a secretive, forest adapted scincid lizard that ranges across the Sunda Shelf.
View Article and Find Full Text PDFGenetic polymorphisms of DNA double-strand break repair pathway genes and glioma susceptibility.
BMC Cancer
May 2013
Department of Neurosurgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
Background: Genetic variations in DNA double-strand break repair genes can influence the ability of a cell to repair damaged DNA and alter an individual's susceptibility to cancer. We studied whether polymorphisms in DNA double-strand break repair genes are associated with an increased risk of glioma development.
Methods: We genotyped 10 potentially functional single nucleotide polymorphisms (SNPs) in 7 DNA double-strand break repair pathway genes (XRCC3, BRCA2, RAG1, XRCC5, LIG4, XRCC4 and ATM) in a case-control study including 384 glioma patients and 384 cancer-free controls in a Chinese Han population.
Polymorphisms in double-strand breaks repair genes are associated with impaired fertility in Chinese population.
Reproduction
May 2013
Nanjing Institute of Environmental Sciences/Key Laboratory of Pesticide Environmental Assessment and Pollution Control, Ministry of Environmental Protection, Nanjing 210042, People's Republic of China.
The DNA double-strand breaks (DSBs) repair pathway plays a critical role in repairing double-strand breaks, and genetic variants in DSBs repair pathway genes are potential risk factors for various diseases. To test the hypothesis that polymorphisms in DSBs genes are associated with susceptibility to male infertility, we examined 11 single nucleotide polymorphisms in eight key DSBs genes (XRCC3, XRCC2, BRCA2, RAG1, XRCC5, LIG4, XRCC4 and ATM) in 580 infertility cases and 580 controls from a Chinese population-based case-control study (NJMU Infertility Study). Genotypes were determined using the OpenArray platform, and sperm DNA fragmentation was detected using the TUNEL assay.
View Article and Find Full Text PDFAssociation of follicular lymphoma risk with BRCA2 N372H polymorphism in Slovak population.
Med Oncol
June 2012
Department of Medical Biology, School of Medicine, University of P. J. Šafárik, Tr. SNP 1, 040 11, Košice, Slovakia.
Follicular lymphoma (FL) is one of the most common Non-Hodgkin lymphoma (NHL) subtype. Only small number of studies concerning NHL and DNA reparation gene polymorphisms has been performed so far. Hence, we have assessed the effect of 4 selected polymorphisms with possible influence on risk of FL development in a case-control study in Slovak population.
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