AI Article Synopsis
- A study using magnetic resonance imaging (MRI) analyzed the prevalence of the cavum septi pellucidi (CSP) in schizophrenia patients, those with schizotypal disorder, and healthy controls, finding similar prevalence rates across all groups.
- The presence of a large CSP (>6 mm) did not significantly differ among the groups, with low percentages in each population (around 6.5% to 10.6%).
- Patients with a large CSP exhibited smaller brain volumes in specific regions, suggesting neurodevelopmental differences, especially in the amygdala and parahippocampal gyrus, in those with schizophrenia spectrum disorders.
Article Abstract
Magnetic resonance imaging was used to evaluate the prevalence of the cavum septi pellucidi (CSP) in 154 schizophrenia patients, 47 schizotypal disorder patients, and 163 healthy controls. We also explored the relation of a large CSP (> or =6 mm) with medial temporal lobe structures. No significant difference was found in the prevalence of the CSP (76.0% of the schizophrenia patients, 81.6% of the controls, and 85.1% of the schizotypal patients) or the large CSP (6.5% of the schizophrenia patients, 7.4% of the controls, and 10.6% of the schizotypal patients) among the groups, but patients with a large CSP (10 schizophrenia and 5 schizotypal patients) had smaller volumes of bilateral amygdala and left posterior parahippocampal gyrus than patients without it. In the control subjects, the large CSP did not affect the volumes of the medial temporal lobe structures. These findings might reflect neurodevelopmental abnormalities in midline and associated limbic structures of the brain in schizophrenia spectrum.
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| http://dx.doi.org/10.1016/j.pnpbp.2007.04.019 | DOI Listing |
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