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Discovery of proteolytically stable monocyte locomotion inhibitory factor peptide through systematic structural optimization.
Eur J Med Chem
January 2025
Institute of Translational Medicine, Shanghai University, Shanghai, 200444, China; Shanghai Integration and Innovation Center of Marine Medical Engineering, China. Electronic address:
The identification of novel molecular candidates capable of treating osteoarthritis (OA) has significant clinical implications. Monocyte locomotion inhibitory factor peptide (MLIF) is a pentapeptide derived from Entamoeba histolytica. It has been found possesses selective anti-inflammatory effects both in vitro and in vivo.
View Article and Find Full Text PDFUnusual Findings of Human-Associated Four-Nucleated Species in Captive Wild Animals.
Animals (Basel)
January 2025
Department of Parasitology, Faculty of Pharmacy, Complutense University, Plaza Ramón y Cajal s/n, 28040 Madrid, Spain.
Several species of amoebae in the genus forming four-nucleated mature cysts are pathogenic, but their identification is challenging due to a lack of distinctive morphological traits. Furthermore, host species cannot reliably be used as a criterion for identification. In this study, several isolates of four-nucleated cyst-forming species from animals at the Zoo Aquarium of Madrid are genetically identified.
View Article and Find Full Text PDFPrevalence and factors associated with intestinal parasitosis in children from an urban slum in Brazil: a cross-sectional study.
Rev Paul Pediatr
January 2025
Universidade Federal de Uberlândia, Faculdade de Odontologia, Uberlândia, MG, Brazil.
Objective: This study aimed to estimate the prevalence and investigate the factors associated with intestinal parasitic diseases in children from an urban slum in Brazil.
Methods: A cross-sectional study was conducted in children living in SEWA community, an urban slum located in Araguari, Minas Gerais, Brazil. The prevalence of intestinal parasitosis was determined via stool parasitological examination by spontaneous sedimentation.
Prevalence and molecular identification of protozoan intestinal parasitic infections in cancer patients and a control group.
BMC Infect Dis
November 2024
Student Research Committee, Fasa University of Medical Sciences, Fasa, Iran.
Article Synopsis
- * The most common protozoan identified in cancer patients was Blastocystis hominis (22.8%), followed by Giardia lamblia and others, while Cystoisospora belli and Cryptosporidium sp. were noted as opportunistic infections.
- * Statistical analysis revealed significant differences in the prevalence of certain infections, such as Blastocystis hominis and Cystoisospora belli, between the two groups, highlighting the risks for immunocompromised patients undergoing chemotherapy.
Molecular detection of potentially zoonotic protozoa in the Chandigarh region, India.
Vet Parasitol Reg Stud Reports
November 2024
Department of Microbiology, Aarupadai Veedu Medical College & Hospital, Puducherry 607403, India. Electronic address:
Context: The contamination of soil by pathogenic protozoan parasites from both human and animal feces, is an important factor in the spread of parasitic infections globally. This contamination also serves as a crucial reservoir for zoonotic diseases, facilitating their transmission. In many developing nations, including India, there's limited documentation on the extent of soil contamination, which poses challenges for implementing effective One Health strategies aimed at controlling these infections.
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