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Amoebas: the omnipotent organism and silent assassin.
Mol Biol Rep
January 2025
Exercise Applied Physiology Laboratory, Biomedical Department, Research Center in High Altitude Medicine and Physiology, Faculty of Health Sciences, University of Antofagasta, Antofagasta, Chile.
Amoebas are characterized by their unique ability to exist both as free-living organisms and, occasionally, as parasites within host tissues, earning them the designation 'amphizoic amoebae'. While amoebic infections are less prevalent, their health impact can be tremendous, leading to several diseases. In low-income countries, poor sanitation and socioeconomic conditions significantly increase the risk of amoebic infections, particularly E.
View Article and Find Full Text PDFFirst Molecular Identification of spp. in Sheep, Beef Cattle, and Dairy Cattle in Shanxi Province, North China.
Vet Sci
January 2025
Laboratory of Parasitic Diseases, College of Veterinary Medicine, Shanxi Agricultural University, Jinzhong 030801, China.
spp. are common zoonotic intestinal protozoa, which can lead to serious intestinal diseases in both humans and animals through fecal-oral transmission, leading to significant economic losses and public health challenges. To reveal the prevalence of in sheep and cattle in Shanxi Province, North China, fecal samples were collected from 311 sheep, 392 dairy cattle, and 393 beef cattle from three representative counties in the northern, central, and southern regions of Shanxi Province.
View Article and Find Full Text PDFAdaptive approach to diagnosis of amebic liver abscess in non-endemic areas.
Diagn Microbiol Infect Dis
January 2025
Division of Infectious Diseases, Naval Medical Center San Diego, 34800 Bob Wilson Drive, San Diego, CA, 92134, USA; Department of Medicine, Uniformed Services University, 4301 Jones Bridge Road, Bethesda, MD 20814, USA.
Entamoeba histolytica infections range from asymptomatic intestinal amebiasis to more severe syndromes like invasive colitis or hepatic abscess. While diagnostic tests available for assessing these infections have evolved, the optimal use of newer diagnostics like enteric multiplex Polymerase Chain Reaction (PCR) panels has not been fully established. Here we describe the case of a 34-year-old male with an amebic liver abscess (ALA) that was diagnosed via multiplex Gastrointestinal (GI) PCR panel on formed stool and subsequently confirmed by testing liver abscess fluid (off-label) on the same multiplex GI PCR panel leading to rapid diagnosis and targeted treatment modification with excellent outcome.
View Article and Find Full Text PDFSerologic diagnosis of Entamoeba histolytica infection based on the gradient-based digital immunoassay.
Anal Chim Acta
February 2025
Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, PR China; Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai, 200032, PR China. Electronic address:
Background: Entamoeba histolytica is a parasite that could cause severe amebiasis, an extremely contagious parasitic disease with critical clinical symptoms. Timely diagnosis and treatment of E. histolytica are crucial for preventing complications and fatalities.
View Article and Find Full Text PDFDiscovery of proteolytically stable monocyte locomotion inhibitory factor peptide through systematic structural optimization.
Eur J Med Chem
January 2025
Institute of Translational Medicine, Shanghai University, Shanghai, 200444, China; Shanghai Integration and Innovation Center of Marine Medical Engineering, China. Electronic address:
The identification of novel molecular candidates capable of treating osteoarthritis (OA) has significant clinical implications. Monocyte locomotion inhibitory factor peptide (MLIF) is a pentapeptide derived from Entamoeba histolytica. It has been found possesses selective anti-inflammatory effects both in vitro and in vivo.
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