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Dengue-virus-induced humoral immunity can increase the risk of severe disease, but the factors influencing this response are poorly understood. Here, we investigate the contribution of CD4 T cells to B cell responses in human dengue infection. We identify a dominant peripheral PD-1 T cell subset that accumulates in severe patients and could induce B cell differentiation via interleukin-21 (IL-21)-related pathway.

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Assessing the global dengue burden: Incidence, mortality, and disability trends over three decades.

PLoS Negl Trop Dis

March 2025

Department of Pathogen Biology, Anhui Province Key Laboratory of Zoonoses, The Provincial Key Laboratory of Zoonoses of High Institutions in Anhui, School of Basic Medical Sciences, Anhui Medical University, Hefei, China.

Background: Dengue, the fastest-spreading vector-borne disease (VBD), significantly burdens global health systems. This study analyzed the trends in the global burden of dengue from 1990 to 2021, utilizing data from the Global Burden of Diseases, Injuries, and Risk Factors Study 2021 (GBD 2021).

Methodology/principal Findings: We retrieved data from GBD 2021 regarding dengue, including the number of incidences and age-standardized incidence rate (ASIR), the number of deaths and age-standardized death rate (ASDR), disability-adjusted life-years (DALYs) and age-standardized DALYs.

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Introduction: The incidence of dengue and its complications increases globally, mainly in areas where it is endemic; however, little literature evaluates outcomes in kidney transplant recipients (KTR). The present analysis aimed to determine the incidence, signs and symptoms, and allograft dysfunction in dengue-infected KTR.

Methods: Systematic review of the literature following PRISMA 2020 indications with studies included until November 24, 2023.

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[Dengue fever vaccination Recommendations from the Société Francophone de Médecine Tropicale et de Santé Internationale for Metropolitan France and Overseas Territories].

Med Trop Sante Int

December 2024

Président de la SFMTSI, SFMTSI Société francophone de médecine tropicale et santé internationale (ancienne SPE), Hôpital Pitié-Salpêtrière, Pavillon Laveran, 47-83 Boulevard de l'Hôpital, 75651 Paris cedex 13, France.

Dengue fever is spreading rapidly around the world, affecting nearly half the world's population. Causes include urbanization, human mobility, climate change and the spread of mosquito vectors such as In 2023 and 2024, there was a marked increase in cases and deaths worldwide. In mainland France, the increase in imported cases has generated local transmissions.

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Uncovering the surge: dengue fever on the rise.

Front Epidemiol

February 2025

Department of Internal Medicine, Howard University, Washington, DC, United States.

Introduction: Dengue fever, traditionally a tropical disease, has shown a notable increase in incidence within the United States over recent decades. This paper focuses on the increase in dengue fever cases in Maryland during increasing temperature and humidity and the expanding geographical range of Aedes mosquitoes, the primary vectors for dengue virus transmission.

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