A series of marine alkaloid 8,9-dihydrocoscinamide B, its analogues and indolylglyoxylamide derivatives have been synthesized and screened for their in vitro antileishmanial activity profile in promastigote and amastigote models. Compounds 7 and 10 have shown 99-100% inhibition against promastigotes and 97-98% inhibition against amastigotes at a concentration of 10 microg/ml.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.bmcl.2007.04.035 | DOI Listing |
Publication Analysis
Top Keywords
marine alkaloid
8
alkaloid 89-dihydrocoscinamide
8
89-dihydrocoscinamide analogues
8
synthesis marine
4
analogues novel
4
novel class
4
class antileishmanial
4
antileishmanial agents
4
agents series
4
series marine
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!