Contact dermatitis is a significant cause of skin disease in geriatric patients. We discuss factors that predispose older adults to contact dermatitis, such as changes in barrier function and types of commonly contacted irritants and allergens.
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Med J Armed Forces India
December 2024
Professor & Head, Department of Pediatrics, Armed Forces Medical College, Pune, India.
J Invest Dermatol
December 2024
Department of Dermatology, Venereology and Allergology, University Hospital Würzburg, 97080 Würzburg, Germany. Electronic address:
A plethora of data supports a major role of CD4 and CD8 T lymphocytes for the initiation, progression and maintenance of allergic contact dermatitis (ACD). However, in-depth understanding of the molecular mechanisms is still limited. NFATc1 plays an essential role in T cell activation.
View Article and Find Full Text PDFContact Dermatitis
December 2024
Dermato-Allergology and Occupational Dermatology, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
Background: In Amsterdam, a steep increase in positive reactions to propolis in the European baseline series was observed from 2.8% in 2020 to 16.4% in 2023.
View Article and Find Full Text PDFEnviron Toxicol Pharmacol
December 2024
Department of Pharmacy and Pharmaceutical Sciences, National University of Singapore, Lower Kent Ridge Road, 4 Science Drive 2, Singapore 117544. Electronic address:
The metabolic conversion of aromatic amines to N-acetylated forms in skin and keratinocytes depends on N-acetyltransferase-1 (NAT1). Common hair color ingredient such as para-phenylenediamine (PPD) causes allergic contact dermatitis. We explored how different electronic substituents on PPD aided NAT1 enzyme biotransform oxidative arylamine (AA) compounds G1-G13 by N-acetylation, NAT-1 activity assays, metabolism, and in vitro clearance investigations in human keratinocytes, while identifying NAT-1 protein levels by Western blot and qRT-PCR.
View Article and Find Full Text PDFContact Dermatitis
December 2024
Aneurin Bevan University Health Board, St. Woolos Hospital, Newport, UK.
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